I. FINANCING OF PRIVATE BIOTECHNOLOGY COMPANIES: $103.4M

Company

Location

Date

Amt. (M)

Investors

Compugen Ltd. (2nd round)

Tel Aviv, Israel

12/15

$15

Clal Biotechnology Industries led this financing round, which included other new investors Hapoalim Investments, Ampal, Evergreen Funds and Cayrex Private Equity

CytoLogix Corp. (2nd round)

Cambridge, Mass.

12/2

$5.4

The principal investors in this financing round included Advanced Technology Ventures, Oxford Bioscience Partners, Hambrecht & Quist, Massachusetts Technology Development Corp. and the Community Technology Fund of Boston University; these same investors participated in CytoLogix's 1st-round financing in 1/98

Novirio Pharmaceuticals Ltd.

Cambridge, Mass.

12/14

$12

This financing was led by BB Bioventures LP and managed by MPM Asset Management (start-up financing)

Ontogeny Inc. (mezzanine-plus)

Cambridge, Mass.

12/1

$28

This financing was led by Vulcan Ventures and other existing investors Charles River Ventures, Greylock Management, Highland Capital Partners, J.H. Whitney & Co., affiliates of Medical Science Partners, New York Life Insurance Co., OneLiberty Ventures, Sutter Hill Ventures and Alex Zaffaroni; they were joined by new investors Atwill Holdings Ltd., Fujigin Capital Co., Moss Forest Venture, Muzinich & Co., New England Partners, New Medical Technologies and five select individual investors

OraPharma Inc. (2nd round)

Warminster, Pa.

12/14

$16

Existing investors participating in this financing round (series C stock) included Oak Investment Partners, Canaan Partners, TL Ventures and Frazier & Co.; new investors were led by Domain Associates and included HealthCap KB, Biotechnology Investments Ltd. and SenMed Medical Venture

Pangea Systems Inc. (2nd round)

Oakland, Calif.

12/14

$15

This Series C financing round was led by MDS Capital Corp. and Boston Millennia Partners; also participating were previous investors Institutional Venture Partners, Mayfield Fund and Kleiner Perkins Caufield & Byers as well as new investors Levensohn Capital Management and Moss Forest Ventures

Scriptgen Pharmaceuticals Inc. (3rd round)

Waltham, Mass.

12/15

$12

Scriptgen sold $12M of convertible preferred stock to new investors Sofinov and a fund managed by International Biomedicine Partners

II. MILESTONE PAYMENTS AND EQUITY INVESTMENTS FROM CORPORATE PARTNERS: $1.0M

Company (Symbol)

Partner (Symbol; Country)

Amt. (M)

Triggering Event

Details (Date)

IntraBiotics Pharmaceuticals Inc.*

Pharmacia & Upjohn Inc. (NYSE:PNU; U.K.)

$1

Completion of Phase I trial on Protegrin IB-367

The companies entered an agreement in 10/97 to develop and market the topical antimicrobial compound IB-367 (synthetic peptide based on natural host defense peptide protegrin) for treating oral mucositis; IntraBiotics completed the Phase I trial, triggering a $1M milestone (12/1)

III. PIPE/REG. S FINANCINGS: $85.2M

Company

Type

Amount

Number Of Shares/Units (M)

Share/Unit Price

Discount

Placement Agent (Date)

Inhale Therapeutic Systems Inc. (INHL)

PIPE

$37.2

1.2S

$31.00

2%

Inhale sold 1.2M newly issued shares of common stock at $31.00 each to the Smallcap World Fund Inc. and American Variable Insurance Series Growth Fund (both managed by Capital Research and Management Co.); Volpe Brown Whelan & Co. acted as the placement agent (12/10)

Triangle Pharmaceuticals Inc. (VIRS)

PIPE

$48.0

4.8S

$10.00

15%

Triangle sold 4.8M newly issued shares of common stock at $10.00 each to selected institutional and other accredited investors; Vector Securities International Inc. acted as the placement agent (12/15)