Scalable synthesis of portimines helps determine anticancer translation inhibition activities through NMD3
Sep. 26, 2023
The cyclic imine toxins represent a growing family of neurotoxic lipophilic compounds made by a variety of benthic marine dinoflagellate species. These cause many shellfish food poisonings worldwide. Their cyclic nature confers exceptional chemical stability with bioaccumulation, but the inability to synthesize adequate amounts of these molecules has precluded basic research of their mechanisms of action.