Using machine learning as an innovative tool for analyzing complex biological systems, researchers integrated bioinformatics with adaptive algorithms and identified dynein light chain LC8-type 2 (DYNLL2) as a key modulator of sepsis progression. Mechanistically speaking, DYNLL2 interacts with p21-activated kinase 1 (PAK1) to regulate bacterial outer membrane vesicle (OMV) internalization and caspase-11 activation.