Hyperuricemia is defined as elevated uric acid levels in serum, usually exceeding 6.8 mg/dL, and the primary pathological cause of gout. Chinese investigators have reported recent results on the urate transporter 1 (URAT1) inhibitor HYJ-2 for the potential treatment of hyperuricemia.
Innorna Co. Ltd. has obtained IND clearance from the FDA for IN-026, enabling the company to initiate a phase I study of this mRNA-based therapy for refractory gout.
Interleukin 1 receptor accessory protein (IL1RAP) is a receptor that activates signaling pathways triggered by IL1α/β, IL33 and IL36α/β/γ, which are involved in several autoimmune or inflammatory disorders, including psoriasis, gout or systemic sclerosis. Innovent Biologics Co. Ltd. presented data for their anti-IL1RAP antibody IBI-3011, a fully humanized IgG1 antibody targeting IL1RAP that blocks those pathways.
University of Lausanne has reported promising preclinical data on SAN-523, a first-in-class positive allosteric modulator of cystathionine gamma-lyase (CSE), developed as a potential therapeutic for microcrystalline arthropathies, including gout and calcium pyrophosphate deposition (CPPD) disease.
In gout, excessive levels of uric acid in the blood lead to deposition of urate crystals in joints, which can cause strong inflammatory pain. Effectively treating gout involves mitigating not only the pain due to inflammatory responses, but also reducing uric acid levels in the blood, such as by inhibiting the uric acid transporter URAT1.
Researchers from Nanjing University and Peking University presented the discovery and preclinical characterization of novel NLRP3 inhibitors as potential therapeutic candidates for the treatment of gout.
Chemokine CXCL5 is an inflammatory mediator and a powerful neutrophil chemoattractant, which mainly acts through CXCR2 to produce its biological effects.
Monte Rosa Therapeutics Inc. has initiated IND-enabling studies with MRT-8102, a potent, highly selective and orally bioavailable NIMA-related kinase 7 (NEK7)-directed molecular glue degrader.
Proabtech Co. Ltd. investigators have published findings from the preclinical characterization of PAT-101, a novel recombinant human albumin (rHA)-conjugated urate oxidase (Uox) variant, being developed for the treatment of gout.
