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Home » Topics » Science » Drug resistance

Drug resistance
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Klebsiella pneumoniae colonies in petri dish
Infection

Boronic acid inhibitors restore cefepime efficacy in multidrug-resistant KPC-producing K. pneumoniae

Feb. 14, 2025
The boronic acid transition state inhibitors S-02030 and MB-076 were strategically designed to be active against cephalosporinases and carbapenemases, especially KPC (Klebsiella pneumoniae carbapenemase).
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Cancer

APD-94, a dual functional inhibitor of Bmi-1 and tubulin

Feb. 14, 2025
Researchers from Hebei Normal University and affiliated organizations presented the discovery and preclinical characterization of a novel B lymphoma Mo-MLV insertion region 1 (Bmi-1) expression inhibitor, APD-94, designed as an agent that could potentially overcome drug resistance in patients with colorectal cancer.
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Bacterial colonies in petri dishes
Infection

Gates Foundation, Novo Nordisk Foundation and Wellcome set sights on antimicrobial resistance

Feb. 13, 2025
The Gates Foundation, Novo Nordisk Foundation and Wellcome have announced the launch of the Gram-Negative Antibiotic Discovery Innovator (Gr-ADI), a $50 million investment that will focus on combatting antimicrobial resistance (AMR) caused by a specific range of bacteria that are among the leading contributors to AMR-associated deaths.
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3D illustration of pancreatic cancer
Cancer

Combined strategy can prevent pancreatic cancer drug resistance

Jan. 31, 2025
By Mar de Miguel
Understanding the mechanisms of resistance to cancer treatments is necessary to find effective therapies at different stages of the disease. Scientists at UT Southwestern Medical Center studied the most frequent mutation in pancreatic ductal adenocarcinoma (PDAC), identified an escape route to a therapy in clinical trials, blocked it with another experimental compound and reduced tumors in mice.
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Infection

New carbapenemase identified in C. freundii raises resistance concerns

Jan. 3, 2025
In a recently published study, researchers based at Université Paris-Saclay identified OXA-1186, a novel carbapenemase related to the previously known OXA-198 enzyme, in a clinical isolate of Citrobacter freundii. This discovery underscores the ongoing challenge of antibiotic resistance in bacterial pathogens.
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Illustration of ecDNA inheritance in cancer

Extrachromosomal DNA acts as joker for cancer cells

Nov. 13, 2024
By Mar de Miguel
Cancer therapies can eliminate specific tumors based on their genetic content. However, some cancer cells survive. How do they do it? Part of the answer lies in extrachromosomal DNA (ecDNA), an ace up the tumors’ sleeve to adapt and evade attack. Three simultaneous studies in the journal Nature lay all the cards on the table, revealing ecDNAs’ content, their origin, their inheritance, their influence in cancer, and a way to combat them.
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Illustration of ecDNA inheritance in cancer

Extrachromosomal DNA acts as joker for cancer cells

Nov. 12, 2024
By Mar de Miguel
Cancer therapies can eliminate specific tumors based on their genetic content. However, some cancer cells survive. How do they do it? Part of the answer lies in extrachromosomal DNA (ecDNA), an ace up the tumors’ sleeve to adapt and evade attack. Three simultaneous studies in the journal Nature lay all the cards on the table, revealing ecDNAs’ content, their origin, their inheritance, their influence in cancer, and a way to combat them.
Read More
Illustration of ecDNA inheritance in cancer
Cancer

Extrachromosomal DNA acts as joker for cancer cells

Nov. 11, 2024
By Mar de Miguel
Cancer therapies can eliminate specific tumors based on their genetic content. However, some cancer cells survive. How do they do it? Part of the answer lies in extrachromosomal DNA (ecDNA), an ace up the tumors’ sleeve to adapt and evade attack. Three simultaneous studies in the journal Nature lay all the cards on the table, revealing ecDNAs’ content, their origin, their inheritance, their influence in cancer, and a way to combat them.
Read More
Concept art for targeting cancer
Immuno-oncology

Genome & Co. stresses CNTN4-APP as next immuno-oncology target

Oct. 29, 2024
By Marian (YoonJee) Chu
Genome & Co. Ltd. has reported preclinical findings of its anti-CNTN4 antibody, GENA-104A16, and anti-APP antibody, 5A7 — stressing the contactin-4 (CNTN4) and amyloid precursor protein (APP) axis as a potential target for immuno-oncology. In the latest murine experiments, investigators led by Genome executives and researchers of Gwangju Institute of Science and Technology (GIST) found that blocking the interaction between CNTN4 and APP promoted cancer-destroying responses in mice, suggesting the pathway as a target for immunotherapy.
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Bacterial colonies in petri dishes
Infection

Novel quinolone-derivative tackles microbial resistance

Aug. 26, 2024
The inappropriate use of antibiotics over long periods of time has led to increasing bacterial drug resistance. Quinolones are among the most effective and widely used antibacterials, and there are ongoing efforts to develop new quinolone-based drugs able to overcome emerging bacterial drug resistance.
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