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BioWorld - Wednesday, January 21, 2026
Home » Topics » Clinical

Clinical
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Figure from journal article showing brain–behavior correlations

Ultrasound improves cognitive performance in Alzheimer's patients

Aug. 12, 2021
By Annette Boyle
A less controversial option than aducanumab may be available soon to help individuals with mild to moderate Alzheimer’s disease-related dementia. Researchers at the Medical University of Vienna and the University of Toronto have developed a technique using ultrasound that reverses cognitive decline and they say it could be available for clinical use shortly.
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Blood sample, DNA

Belief Biomed’s BBM-H901 wins first Chinese IND approval in gene therapy for hemophilia B

Aug. 12, 2021
By Doris Yu
China’s NMPA has given Belief Biomed Inc. the official go-ahead to start testing its investigational gene therapy, BBM-H901, for the potential treatment of hemophilia B in the country, marking the first time an I.V. gene therapy for a rare disease has been approved in China. The company plans to advance the phase I/II trial for the candidate shortly, it said.
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No smoking icon

Chantix in a fix, cytisinicline set to Achieve greatness in anti-smoking space?

Aug. 12, 2021
By Randy Osborne
Pfizer Inc.’s voluntary recall of batches of Chantix (varenicline) in mid-July called attention to the smoking-cessation market, where the nicotinic acetylcholine receptor agonist holds lead position, with Glaxosmithkline plc’s Zyban (bupropion) – another oral prescription drug – also a contender. In line to potentially shake up the space with cytisinicline, a plant-based alkaloid, is Achieve Life Sciences Inc.
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Liver disease

Cohbar shares climb as early NAFLD data hint at potential in NASH

Aug. 11, 2021
By Michael Fitzhugh
Shares of Cohbar Inc. (NASDAQ:CWBR) hit a 52-week high on Aug. 11 following news that a mitochondrial peptide analogue it is testing for the potential treatment of nonalcoholic steatohepatitis (NASH) and obesity, CB-4211, delivered "robust" improvements in key biomarkers of liver damage and glucose levels vs. placebo during a small phase Ia/Ib study.
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Red blood cells and coronavirus

Expert panel links AZ vaccine to blood clots, though exact cause remains unknown

Aug. 11, 2021
By Nuala Moran
LONDON – Stopping people under 40 from receiving Astrazeneca plc’s COVID-19 vaccine has put an end to the serious blood-clotting syndrome associated with the product, with no new cases in the U.K. for the past four weeks, according to an expert panel of hematologists.
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In the clinic for Aug. 11, 2021

Aug. 11, 2021
Clinical updates, including trial initiations, enrollment status and data readouts and publications: Apollomics, Athersys, Avacta, Azurrx, Cohbar, Crinetics, Cytoagents, Flexion, Fulcrum, Goldfinch, Grunenthal, Healios, Heparegenix, I-Mab, Immvira, IMV, In8bio, Inflarx, Novaliq, Nrx, Point, Pulmatrix, Reata, Retrotope, Rezolute, Sinovac, Summit, Trevena.
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SARS-CoV-2 illustration turns from blue to red

Chinese vaccines move one step closer to preventing Delta variant COVID-19

Aug. 10, 2021
By Doris Yu
Preliminary real-world data showed that Chinese inactivated vaccines are 63% protective against the COVID-19 Delta variant, China’s top epidemiologist Zhong Nanshan said at the 24th Respiratory Disease Academic Conference of Guangdong Medical Association in Guangzhou.
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AZ, Daiichi Sankyo take aim at Roche as Enhertu beats Kadcyla in breast cancer trial

Aug. 10, 2021
By Richard Staines
Astrazeneca plc and Daiichi Sankyo Co. Ltd. are pushing forward with a challenge to Roche Holding AG with breast cancer drug Enhertu (trastuzumab deruxtecan) after it demonstrated superiority over the Swiss firm’s Kadcyla (trastuzumab emtansine) in a head-to-head trial.
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Coronavac product packaging

Sinovac reports positive data on COVID-19 booster, loss of antibodies within months

Aug. 10, 2021
By Sergio Held
Sinovac Biotech Ltd. said booster shots of its Coronavac vaccine against SARS-CoV-2 induce strong immune responses in adult and elderly populations following a considerable loss of antibodies six to eight months after completing the current two-dose regimen.
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SK Bioscience advances first South Korean-developed COVID-19 vaccine to late-stage testing

Aug. 10, 2021
By Gina Lee
SK Bioscience Ltd. has won approval from the South Korean Ministry of Food and Drug Safety (MFDS) to begin a phase III trial for its COVID-19 vaccine candidate GBP-510, making the recombinant protein antigen vaccine the first domestically developed candidate to make it to late-stage testing. “We aim to begin the phase III trials within August and to have the data ready by early 2022,” a company spokesman told BioWorld.
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