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Researchers from Enanta Pharmaceuticals Inc. presented preclinical data for the small molecule non-nucleoside respiratory syncytial virus (RSV) L-protein inhibitor, EDP-323, being developed for the treatment of RSV infection.
Researchers from Lantern Pharma Inc. presented preclinical data for the small-molecule DNA-damaging agent LP-284, being developed for the treatment of hematological cancers.
While simultaneous targeting of PD-1 and TGF-β has been previously suggested to be a favorable strategy to reverse immune checkpoint inhibitor (ICI) resistance of tumors, the hydrophobicity of TGF-β inhibitors and latent drug-related adverse events of this treatment hindered its utility.
Researchers from the University of Coimbra presented data from a study that aimed to assess the role of the ghrelin/neuropeptide Y (NPY) system in adipose tissue in subjects with obesity and metabolic syndrome.
Cell death induced by hypoxia is quite a common problem during pancreatic islet transplantation and is caused by insufficient revascularization of the grafts. It has been reported that the loss of NLR family pyrin domain containing 3 (NLRP3) in pancreatic islet cells protects them from hypoxia-induced cell death, so it was hypothesized that blockade of NLRP3 would improve pancreatic islet transplantation.
Researchers from the University of Zurich presented data from a study that aimed to investigate the impact of liver-specific apoptosis signal regulating kinase 1 (ASK1) overexpression on the development of high-fat diet (HFD)-induced obesity and impaired glucose metabolism.
Farnesoid X receptor (FXR) is a bile acid-activated receptor and in the gut it is mainly expressed in the ileum, promoting transcription of fibroblast growth factor-19 (FGF-19), a hormone with positive effects on energetic and glucose homeostasis.
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