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Home » Topics » Conferences » American Heart Association Scientific Sessions

American Heart Association Scientific Sessions
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Heart scientific overlay
Cardiovascular

MTX-652 attenuates TAC-induced cardiac dysfunction in vivo

Dec. 4, 2024
Data from a preclinical study assessing Mission Therapeutics Ltd.’s clinical-stage USP30 inhibitor MTX-652, for the prevention of transverse aortic constriction (TAC)-induced cardiac hypertrophy and remodeling, were recently presented.
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Lungs and bronchi
Cardiovascular

GPR39 blockade prevents hypoxia-induced pulmonary artery hypertension

Nov. 29, 2024
Recent findings have unveiled that 15-HETE is the endogenous agonist for G protein-coupled receptor 39 (GPR39) in vascular smooth cells, so researchers hypothesized that GPR39 could work as a therapeutic target in pulmonary arterial hypertension and its deletion might prevent the development of the disease.
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Digital cardiology illustration
Cardiovascular

E-Therapeutics’ B4GALT1-targeting Galomic siRNA demonstrates prolonged duration of action

Nov. 28, 2024
Potent siRNAs against B4GALT1 were designed in silico and screened in vitro (Huh7 cells, primary mouse, human hepatocytes) as well as in vivo (C57BL/6 mice) for the selection of a lead Galomic siRNA.
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Blood clot under microscope.
Hematologic

HD1-12dmA-DAB is a rapid and potent anticoagulant, researchers show

Nov. 27, 2024
Investigators from Duke University hypothesized that hirudin-like protease inhibitors could be generated by linking exosite-binding aptamers with small-molecule active site inhibitors, thus generating more potent “EXACT” inhibitors.
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Human heart within crosshairs
Cardiovascular

ETX-258 improves cardiac function and structural remodeling post-MI

Nov. 21, 2024
At the American Heart Association’s Scientific Sessions, E-Therapeutics plc presented preclinical data for ETX-258, a Galomic siRNA being developed for the treatment of heart failure.
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Cardiovascular

Linoleic acid metabolite reduces atrial arrhythmia by normalizing CaMKII levels

Nov. 21, 2024
Researchers from Ohio State University hypothesized that 12,13-diHOME may act by inhibiting the proarrhythmic molecule Ca2+/calmodulin-dependent kinase II (CaMKII).
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Illustration of human heart with DNA structure background
Cardiovascular

EDG-7500 reverses nonobstructive hypertrophic cardiomyopathy in vivo

Nov. 20, 2024
Hypertrophic cardiomyopathy (HCM) is the most common genetic cardiovascular disorder with around 85% of people with HCM remaining undiagnosed. There are no treatments approved for nonobstructive HCM (nHCM) to date.
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Boston Scientific Corp.’s Watchman Flx device

Boston Sci study shows Watchman Flx better OPTION than DOAC

Nov. 18, 2024
By Annette Boyle
Boston Scientific Corp.’s OPTION study demonstrated left atrial appendage closure with the Watchman Flx device reduced risk of stroke compared to management with direct oral anticoagulants or warfarin in patients with atrial fibrillation following cardiac ablation. Results were presented at the American Heart Association's Scientific Sessions 2024 and simultaneously published in The New England Journal of Medicine.
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Vascular system
Cardiovascular

Solbinsiran siRNA is tested in cardiovascular disease models

Nov. 20, 2023
Eli Lilly and Co. shared insights into an inhibitor targeting ANGPTL3, named solbinsiran. Solbinsiran, a N-acetylgalactosamine (GalNAc) conjugated Dicer-substrate small interfering RNA (DsiRNA), is designed to target ANGPTL3 expression in the liver.
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Cardiovascular

Anti-CD47 BRB-002 shows activity in mouse atherosclerosis model

Nov. 20, 2023
Bitterroot Bio Inc. presented data on an anti-CD47 hybrid protein, BRB-002, tested in a murine model of atherosclerosis. BRB-002 was tested at 2.5 or 10 mg/kg i.p. 3x/week after a high-fat diet. Firstly, BRB-002 was seen to bind CD47 with high affinity in several cell lines, but not in Jurkat CD47-knockout cells.
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