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Home » Topics » Disease categories and therapies » Ear, nose and throat

Ear, nose and throat
Ear, nose and throat RSS Feed RSS

Man holding hand up to ear
Ear, nose & throat

Shionogi enters option agreement for Cilcare’s hearing loss candidates

June 11, 2024
Shionogi & Co. Ltd. has entered into an option agreement with Cilcare Dev SAS to acquire the exclusive license for the global development, manufacturing and commercialization of hearing loss treatment drug candidates CIL-001 and/or CIL-003.
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Ear and sound waves illustration
Biomarkers

DBX2 is a new gene tied to nonsyndromic hearing loss

June 11, 2024
It is known that >70% of the genes involved in pathogenic hearing loss are involved in autosomal recessive nonsyndromic hearing loss (ARNSHL), which accounts for 1 case for every 166 individuals in Iran due to the high rate of consanguineous marriage in the country.
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Man holding hand up to ear
Ear, nose & throat

Shionogi enters option agreement for Cilcare’s hearing loss candidates

June 10, 2024
Shionogi & Co. Ltd. has entered into an option agreement with Cilcare Dev SAS to acquire the exclusive license for the global development, manufacturing and commercialization of hearing loss treatment drug candidates CIL-001 and/or CIL-003.
Read More
Illustration of ear next to DNA double helix
Biomarkers

Study reveals ARHGAP22 behind pathogenesis of nonsyndromic hearing loss

June 4, 2024
One in every 500 newborns worldwide are affected by nonsyndromic hearing loss (NSHL). Whole-exome sequencing may help in identifying the genetic cause of NSHL.
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Ear, Nose and Throat

New 15-PGDH inhibitors detailed in Scinnohub Pharmaceutical patent

Feb. 19, 2024
Work at Scinnohub Pharmaceutical Co. Ltd. has led to the identification of new 15-hydroxyprostaglandin dehydrogenase (15-PGDH) inhibitors.
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Biomarkers

Polymorphism in CX3CR1 may contribute to sensorineural hearing loss

Feb. 13, 2024
It is known that CX3C chemokine receptor 1 (CX3CR1) expressed on macrophages plays a crucial role in inner hair cell ribbon synaptic repair and spiral ganglion neuron survival after synaptopathic noise-induced trauma.
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Illustration of scientists conducting research on a mouse to find the missing puzzle piece
Ear, Nose & Throat

New mouse model of hereditary deafness resulting from common GJB2 mutation

Feb. 12, 2024
The most common genetic cause of hereditary deafness in humans are mutations in the GJB2 gene, especially the 35delG and 235delC mutations. At the recent ARO meeting, researchers from Ear Nose and Throat Hospital of Fudan University presented the creation of a novel mouse model for studying the pathogenic mechanisms of hereditary deafness resulting from these mutations.
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Illustration of ear next to DNA double helix
Biomarkers

USH1C identified as new genetic variant behind progressive hearing loss

Feb. 9, 2024
Harmonin is a key factor in the maintenance of mechanosensory function in hair cells in the ear, and it is encoded by the USH1C gene.
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Ear and sound waves illustration
Ear, Nose & Throat

REV-ERBα agonist shows potential to restore noise-induced hearing loss

Feb. 9, 2024
Noise-induced hearing loss is still the most common cause of acquired hearing loss nowadays. The mechanisms behind this may be explained through inflammatory responses in the cochlea after acoustic trauma.
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Illustration demonstrating parts of the ear
Ear, Nose & Throat

Tizaterkib protects mice from noise-induced hearing loss by lowering immune cell infiltrates into the cochlea

Feb. 8, 2024
It has been previously demonstrated that noise exposure leads to activation of the mitogen-activated protein kinase (MAPK) pathway, and that inhibition of this pathway protects from hearing loss. Tizaterkib (formerly AZD-0364) is a novel, highly selective, orally bioavailable ERK1/2 inhibitor that is currently in early clinical development for the treatment of cancer. In recent work, investigators from Creighton University aimed to assess the potential of tizaterkib for the treatment of noise-induced hearing loss (NIHL).
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