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Home » Topics » Disease categories and therapies » Ear, nose and throat

Ear, nose and throat
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Ear, Nose & Throat

Sensorion's SENS-501 can enter clinic for genetic hearing loss

Jan. 19, 2024
Sensorion SA has received approval in Europe for its clinical trial application (CTA) to initiate a...
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Mindear app

Mindear app reduces tinnitus impact in 64% of users

Jan. 10, 2024
By Tamra Sami
Researchers from the University of Auckland have developed a smartphone app called Mindear that reduced the impact of tinnitus in two-thirds of users over eight weeks.Tinnitus, often referred to as ringing in the ears, is the perception of sound without an external source and affects 10% to 15% of the global adult population. Previous studies to treat tinnitus have focused on neuromodulation devices, but a smartphone app could make treatment more accessible to a wider population.
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Illustration demonstrating parts of the ear
Ear, Nose and Throat

Takara Bio develops novel AAV vector with high gene transfer efficiency to inner ear

Nov. 13, 2023
Takara Bio Inc. has announced the development of a novel adeno-associated virus (AAV) vector, Sonuaav, which exhibits high gene transfer efficiency into inner ear tissues, with a collaborator at Juntendo University School of Medicine.
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Man holding hand up to ear
Ear, Nose and Throat

CSF delivery of AAV-Slc17a8 rescues genetically driven hearing loss in adult mice

July 19, 2023
Researchers from the University of Copenhagen, Karolinska Institutet and affiliated organizations have reported the discovery of a novel gene therapy delivered through a cerebrospinal fluid (CSF) conduit as new treatment strategy for hearing loss.
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Illustration of ear next to DNA double helix
Ear, Nose & Throat

Sensorion submits CTA in UK for OTOF-GF for otoferlin gene-mediated hearing loss

July 10, 2023
Sensorion SA has submitted a clinical trial application (CTA) for OTOF-GT to the U.K.’s Medicines and Healthcare products Regulatory Agency (MHRA). Sensorion plans to submit the CTA in Europe in the coming weeks.
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Man holding hand up to ear
Ear, Nose & Throat

TMPRSS3 gene therapy prolongedly restores hearing in mouse model of human recessive deafness DFNB8

June 9, 2023
Currently, there are no treatments to reverse or prevent genetic hearing loss, which affects 1 in 500 newborns. Several gene replacement and overexpression preclinical studies targeting genetic hearing loss have shown success, as the inner ear can be accessed safely by local injection. However, all these gene therapy studies have been performed in neonatal animals, except one in the Otof gene; therefore, the suitability of the approach in the fully mature adult inner ear remains to be elucidated.
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Ear illustration
Ear, Nose & Throat

Using PCDH15 minigenes to treat hearing loss in USH1F

May 18, 2023
Usher syndrome is the most common cause of deaf-blindness. Mutations in the protocadherin-15 (PCDH15) gene cause Usher syndrome type 1 F (USH1F), which makes up about 3-11% of all Usher syndrome cases. As a component of tip links of the inner ear hair cells, PCDH15 binds to cadherin-23 (CDH23) to convey force from sound stimuli to the mechanosensory transduction channels.
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Ear and sound waves illustration
Ear, Nose and Throat

Sensorion selects candidate in GJB2-related hearing loss program

April 6, 2023
Sensorion SA has selected a candidate in its...
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Man holding hand up to ear
Ear, Nose & Throat

Researchers create humanized mouse model for DFNA9 carrying the p.P51S variant of COCH gene

Feb. 22, 2023
Researchers from the University of Antwerp reported the characterization of a novel clinically relevant mouse model of DFNA9 (deafness, autosomal dominant 9), an autosomal dominant inherited disorder characterized by vestibular dysfunction and adult-onset progressive hearing loss caused by different heterozygous mutations in the COCH gene.
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Lab mouse
Ear, Nose and Throat

WFS1 gene plays crucial roles in cochlear maintenance and hair cell survival, murine model shows

Feb. 20, 2023
Wolfram syndrome is a neurodegenerative disease characterized by neurological symptoms, as well as diabetes, optic atrophy and hearing loss, among others. The WFS1 gene encodes a protein named Wolframin and it accounts for about 99% of cases, 60% of which present with hearing loss. To date, of all animal models of Wolfram syndrome developed carrying a variant or deletion of one exon of Wfs1, none mimics the early-onset hearing loss.
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