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BioWorld - Tuesday, June 24, 2025
Home » Topics » Disease categories and therapies » Ear, nose and throat

Ear, nose and throat
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Ear, nose & throat

Antioxidants for hearing loss and Meniere’s disease disclosed in Primemupharma patent

Oct. 15, 2024
Primemupharma Co. Ltd. has divulged compounds comprising a novel polyester linker acting as antioxidants reported to be useful for the treatment of hearing loss and Meniere’s disease.
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Ear, nose & throat

New gene therapy for hereditary hearing loss described

Oct. 15, 2024
More than half of all hearing loss cases are hereditary. Myelin protein zero-like 2, encoded by MPZL2, is widely expressed in cochlear cells in the inner ear. Mutations in MPZL2 have been identified as the second most prevalent cause of mild to moderate hereditary hearing loss.
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Man holding hand up to ear
Ear, nose & throat

Piplartine counteracts antibiotic-induced hearing loss

Aug. 13, 2024
Piplartine, also called piperlongumine, had protective effects against hearing loss induced by aminoglycoside antibiotics in zebrafish and mouse models of kanamycin-induced hair cell loss. Kanamycin is a member of the aminoglycosides, a group of antibiotics that have broad-spectrum activity against gram-negative bacteria, including multidrug resistant strains.
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Closeup of a mouse
Ear, nose & throat

Mouse model of profound deafness linked to a Cdh23 variant

Aug. 7, 2024
A spontaneous homozygous deletion affecting the copy number of the cadherin 23 (Cdh23) gene in a line of laboratory mice gave rise to a new murine model with hereditary hearing loss and vestibular alterations.
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Big pharma’s ear to the ground as hearing-loss drum beats louder

July 12, 2024
By Randy Osborne
The primary-endpoint win by Sensorion SA in a phase II proof-of-concept study with SENS-401 (arazasetron) in hearing loss made public March 11 brought renewed interest in the space, where a number of players are advancing gene therapies. The story marches on, with Montpellier, France-based Sensorion due to discuss the product July 13 at the International Conference on Cochlear Implants and Other Implantable Technologies in Vancouver, British Columbia.
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Illustration demonstrating parts of the ear

A gene therapy could restore hearing in adults

July 12, 2024
By Mar de Miguel
Patients with congenital hearing loss could benefit from a gene therapy currently in development. Although there are approaches that could reverse the process in children and young people before it becomes severe, so far, adults do not have any treatment that prevents the progressive deterioration of auditory sensory cells caused by this disease.
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Illustration demonstrating parts of the ear
Drug design, drug delivery & technologies

A gene therapy could restore hearing in adults

July 11, 2024
By Mar de Miguel
Patients with congenital hearing loss could benefit from a gene therapy currently in development. Although there are approaches that could reverse the process in children and young people before it becomes severe, so far, adults do not have any treatment that prevents the progressive deterioration of auditory sensory cells caused by this disease.
Read More
Man holding hand up to ear
Ear, nose & throat

Shionogi enters option agreement for Cilcare’s hearing loss candidates

June 11, 2024
Shionogi & Co. Ltd. has entered into an option agreement with Cilcare Dev SAS to acquire the exclusive license for the global development, manufacturing and commercialization of hearing loss treatment drug candidates CIL-001 and/or CIL-003.
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Ear and sound waves illustration
Biomarkers

DBX2 is a new gene tied to nonsyndromic hearing loss

June 11, 2024
It is known that >70% of the genes involved in pathogenic hearing loss are involved in autosomal recessive nonsyndromic hearing loss (ARNSHL), which accounts for 1 case for every 166 individuals in Iran due to the high rate of consanguineous marriage in the country.
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Man holding hand up to ear
Ear, nose & throat

Shionogi enters option agreement for Cilcare’s hearing loss candidates

June 10, 2024
Shionogi & Co. Ltd. has entered into an option agreement with Cilcare Dev SAS to acquire the exclusive license for the global development, manufacturing and commercialization of hearing loss treatment drug candidates CIL-001 and/or CIL-003.
Read More
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