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Home » Topics » Disease categories and therapies » Hematologic

Hematologic
Hematologic RSS Feed RSS

Takeda moves mezagitamab to phase III in thrombocytopenia

June 24, 2024
By Tamra Sami
Takeda Pharmaceutical Co. Ltd. is progressing mezagitamab to phase III trials after the CD38 monoclonal antibody showed rapid and sustained increases in platelet counts in patients with persistent or chronic primary immune thrombocytopenia (ITP) in a phase IIb trial.
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Genentech’s Piasky cleared for paroxysmal nocturnal hemoglobinuria

June 24, 2024
By Karen Carey
Roche Holding AG’s Genentech Inc. unit received U.S. FDA approval on June 20 of Piasky (crovalimab) to treat adults and children 13 and older with paroxysmal nocturnal hemoglobinuria and a body weight of at least 40 kg (88 pounds).
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Hematologic

Potential first-in-class agent for JAK2 V617F mutant myeloproliferative neoplasms

June 21, 2024
Researchers from Incyte Corp. and collaborators presented the preclinical profile of INCB-160058, an ATP-competitive small-molecule inhibitor of the JAK2 V617F mutant sparing its wild-type (WT) form, designed for the treatment of JAC2 V617F mutation-positive myeloproliferative neoplasms with potential as a first-in-class JAK2 V617-inhibiting drug.
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Hematologic

Incyte’s anti-CALR displays robust antimyeloproliferative effect

June 20, 2024
Among the acquired mutations in the calreticulin (CALR) gene, both 52 bp deletion (del52) and 5 bp insertion (ins5) are among the most frequent and are linked to two different types of myeloproliferative neoplasms (MPNs).
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Thrombus in bloodstream with platelets and fibrin
Hematologic

IP receptor agonist CS-585 efficacious as thrombosis therapeutic

June 19, 2024
Aberrant overactivity of platelets may lead to the formation of occlusive thrombi and consequently lead to myocardial infarction or stroke. At the recent EHA meeting, researchers from the University of Michigan and Cereno Scientific AB presented data regarding their prostacyclin (IP) receptor agonist CS-585 as a thrombolytic.
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Handshake behind digital globe

Takeda, Ascentage in $1.2B option agreement for olverembatinib

June 18, 2024
By Tamra Sami
Takeda Pharmaceutical Co. Ltd. has signed an option agreement to in-license Ascentage Pharma Group Inc.’s olverembatinib, an oral third-generation BCR-ABL tyrosine kinase inhibitor (TKI). If exercised, the option would allow Takeda to license exclusive global rights to develop and commercialize olverembatinib in all territories outside of mainland China, Hong Kong, Macau, Taiwan and Russia.
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Photomicrograph of diffuse large B-cell lymphoma
Hematologic

Arvina’s BCL6 protein degrader shows high antiproliferative activity

June 18, 2024
B-cell lymphoma 6 (BCL6) is up-regulated in several B-cell malignancies where it acts as a transcription factor activity mediator to induce and maintain lymphomagenesis.
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Handshake behind digital globe

Takeda, Ascentage in $1.2B option agreement for olverembatinib

June 17, 2024
By Tamra Sami
Takeda Pharmaceutical Co. Ltd. has signed an option agreement to in-license Ascentage Pharma Group Inc.’s olverembatinib, an oral third-generation BCR-ABL tyrosine kinase inhibitor (TKI). If exercised, the option would allow Takeda to license exclusive global rights to develop and commercialize olverembatinib in all territories outside of mainland China, Hong Kong, Macau, Taiwan and Russia.
Read More
Acute myeloid leukemia illustration
Hematologic

EHA 2024: Spotlight on first-in-class translational research in blood cancer

June 17, 2024
By Coia Dulsat
The first oral session in the acute myeloid leukemia (AML) translational research track of June 15, was given by Eliza Yankova, from the University of Cambridge, who presented collaborative studies done together with Storm Therapeutics Ltd. outlining pharmacological inhibition of METTL1 as a therapeutic strategy in AML treatment.
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AI-generated image of blood cells in a bone marrow biopsy
Hematologic

EHA 2024: Calreticulin is up-and-coming target in myeloproliferative disorders

June 14, 2024
By Coia Dulsat
Myeloproliferative neoplasms (MPNs) can only be cured, to date, using allogeneic stem cell transplantation which, in turn, only works for up to 20% of patients. As calreticulin (CALR) frameshift mutations are the second most common cause of MPNs, targeting this endoplasmic reticulum resident protein is one of the strategies emerging at the forefront of hematological malignancies research.
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