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BioWorld - Sunday, May 22, 2022
Home » Topics » Inflammatory, BioWorld

Inflammatory, BioWorld
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Back pain

Inflammation is key to preventing chronic pain, study finds

May 11, 2022
By Anette Breindl
No Comments
More than 10% of Americans suffer from chronic pain, and how to prevent acute pain from turning chronic has been a critical question in pain research. But according to a study published in the May 11, 2022, issue of Science Translational Medicine, that approach has it backwards. In several animal models of pain, the resolution of acute pain was an active process. Chronic pain happened when those active processes failed to occur.
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Knee pain illustration

Juniper Biologics acquires gene therapy for knee osteoarthritis in $600M deal from Kolon Life Science

April 14, 2022
By David Ho and Gina Lee
No Comments
Through a $600 million deal, Juniper Biologics Pte. Ltd. has acquired rights from Kolon Life Science Inc. to develop and commercialize TG-C LD (Tissuegene-C low dose) for the treatment of knee osteoarthritis. Singapore-based Juniper will hold the rights for Asia Pacific, the Middle East and Africa and be responsible for developing and commercializing the candidate within those regions.
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Atom Bioscience planning phase III gout trial after encouraging mid-stage readout

March 25, 2022
By Doris Yu
No Comments
Jiangsu Atom Bioscience and Pharmaceutical Co. Ltd., a company developing an oral a urate anion exchanger 1 inhibitor for the potential treatment of chronic gout, said results of a phase IIa trial show that its lead candidate, ABP-671, reduced serum uric acid levels to less than 6 mg/dL, below the clinically defined threshold of 7 mg/dL for hyperuricemia, or excess of uric acid in the blood, which leads to gout.
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Outline of intestine and person holding stomach in painntestine on person holding stomach in pain

Pfizer’s $6.7B Arena buy looks sound after positive phase III readout from etrasimod

March 23, 2022
By Richard Staines
No Comments
One of Pfizer Inc.’s last decisions of 2021 was to shell out $6.7 billion for San Diego’s Arena Pharmaceuticals Inc., a deal centered around the pipeline inflammatory disease pill etrasimod. A potential successor to Xeljanz (tofacitinib), the price New York-based Pfizer paid suggests blockbuster potential for etrasimod. Phase III results announced March 23 suggest Pfizer’s big acquisition, the fifth largest in biopharma in 2021, was money well spent.
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Huadong acquires Asia rights to drugs from Kiniksa in $662M deal

Feb. 25, 2022
By Doris Yu
No Comments
Huadong Medicine Co. Ltd.’s wholly owned subsidiary Hangzhou Zhongmei Huadong Pharmaceutical Co. Ltd. has acquired Asia-Pacific rights to two drugs from Kiniksa Pharmaceuticals Ltd. in a deal worth up to $662 million. “This collaboration aims to bring Kiniksa’s therapeutics to patients in the Asia Pacific Region suffering from severe autoimmune and inflammatory diseases,” said Sanj Patel, chairman and CEO of Kiniksa. “The collaboration also provides nondilutive capital, cost-sharing, and resources for clinical trials to accelerate our drug development and commercialization efforts.”
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Skin irritation on hands

Balance beam: Third Harmonic’s start value high in KIT, scores $105M series B

Feb. 16, 2022
By Randy Osborne
No Comments
Third Harmonic Bio Inc. CEO Natalie Holles said the company’s $105 million in series B money will push THB-001 – a first-in-class, highly selective, oral inhibitor of wild-type KIT – “well past the first proof-of-concept study in inducible urticaria [hives].”
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A Star is born as new SIRP player aims to Electra-fy rare disease

Feb. 16, 2022
By Randy Osborne
No Comments
Star Therapeutics Inc. emerged from stealth mode to tell the world about its approach to drug discovery and development in rare diseases, and to spin out Electra Therapeutics Inc., the first in a projected family of companies.
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Biotech deal illustration

Innovent options China rights to Amagma candidates for inflammatory disorders

Jan. 21, 2022
By Doris Yu
No Comments
Innovent Biologics Inc. has secured an option to license China rights for up to three enzyme specific inhibitors for inflammatory disorders with few or no treatments from Amagma Therapeutics Inc. Innovent will also manufacture the inhibitors for a phase II trial in the region.
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STATute of limitations? Time running out for ‘undruggable’ SH2 as Recludix bags $60M series A

Nov. 15, 2021
By Randy Osborne
No Comments
Recludix Pharma Inc. launched with a $60 million series A round to target Src homology 2 (SH2) domains, and the new money will get the San Diego-based firm to reach the IND-enabling stage, CEO Nancy Whiting told BioWorld.
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Clinical research concept with medical icons on light bulb

Finding needles in haystacks: Omass unveils pipeline aimed at tough-to-drug targets

Nov. 15, 2021
By Nuala Moran
No Comments
LONDON – There’s not yet proof of the pudding, but Omass Therapeutics Ltd.’s new structure-based technology has passed a key test, in enabling the discovery of orally available small molecules aimed at intractable and poorly drugged membrane and complex-bound protein targets. The targets, including G protein-coupled receptors (GPCRs), intracellular protein complexes and solute carriers, are relevant to immunology indications and rare diseases with high unmet need.
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