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BioWorld - Saturday, April 4, 2026
Home » Topics » Inflammatory, BioWorld

Inflammatory, BioWorld
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Cancer and blood cells

Hematopoietic stem cell research points to leukemia’s early roots

April 2, 2026
By Marian (YoonJee) Chu
No Comments
Hematopoietic stem cell research over the past century has shown that leukemia may be driven by an invisible hand of inflammation. The bone marrow and inflammation, then, may hold the keys to preventing blood cancers, according to John E. Dick’s plenary session at the 2026 Korean Society of Hematology International Conference, held March 26, 2026.
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PET scans showing before and after treatment with VIPOR
ICKSH 2026

Five-drug VIPOR regimen shows promise in aggressive blood cancer

April 1, 2026
By Marian (YoonJee) Chu
No Comments
Deep molecular advances are enabling precision medicine for the field of hematology, Wyndham Wilson said during a plenary session at the 2026 Korean Society of Hematology International Conference March 26.
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Liver over digital lens background

US FDA warns of liver injuries, 8 deaths associated with Tavneos

April 1, 2026
By Mari Serebrov
No Comments
Once again, Amgen Inc.’s Tavneos (avacopan) is under U.S. FDA scrutiny, as the agency alerted patients and doctors March 31 about 76 cases of drug-induced liver injury, including eight deaths, with “reasonable evidence of a causal association” with the drug.
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Handshake icon engraved on metal hexagonal background

Galapagos enters new era as Lakefront after reshaping Gilead alliance

March 31, 2026
By Nuala Moran
No Comments
Galapagos NV is about to bury its recent turbulent past and sail off for the future with its $3 billion cash pile and the new name of Lakefront Biotherapeutics NV. The foundation for the transition was laid earlier this month in an arrangement with Gilead Sciences Inc., holder of 25% of Galapagos’ equity, to “co-parent” the assets of Ouro Medicines LLC, which Gilead is acquiring for up to $2.17 billion.
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Hands holding gears

Gilead pens dual-purpose $2B Ouro M&A deal with Galapagos

March 24, 2026
By Marian (YoonJee) Chu
No Comments
Gilead Sciences Inc. said after U.S. market close March 23 that it will acquire privately held Ouro Medicines LLC and its autoimmune BCMA/CD3 bispecific T-cell engager, gamgertamig, in a deal valued at $2.17 billion.
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Gastrointestinal system with DNA, scientific background

Somatic genomics pioneer Quotient signs $2.2B IBD deal with Merck

March 24, 2026
By Karen Carey
No Comments
For a company founded only four years ago, Quotient Therapeutics Inc. entered its third major deal, this time with Merck & Co. Inc. to find novel drug targets for inflammatory bowel disease (IBD) using its somatic genomics platform technology.
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Illustration of Alzheimer's disease in the brain

ADPD 2026: Three inflection points to target Alzheimer’s disease

March 20, 2026
By Mar de Miguel
No Comments
A new way of understanding Alzheimer’s disease, based on biological inflection points that mark decisive moments in the progression of the disorder, could change how new drugs are developed to achieve more effective therapies. This new perspective could rethink strategies that depend not so much on the target itself, but on the precise moment at which it is addressed.
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MRI image brain on black background
Neurology/psychiatric

ADPD 2026: Can we prevent dementia? Scientists quantify it

March 18, 2026
By Mar de Miguel
No Comments
Neurodegenerative disease and cognitive decline cannot be explained by a single process. Beta-amyloid plaques, hyperphosphorylated tau, alpha-synuclein, activated microglia and astrocytes, altered receptors such as TREM2, mitochondrial dysfunction, epigenetic changes and cerebrovascular alterations all seem to contribute to the development of dementia in Alzheimer’s disease (AD). While scientists attempt to address each of these elements, prevention is growing as a primary goal.
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Fibroblast illustration
Cancer

Mestag raises $40M to take fibroblast program into phase I cancer trial

March 17, 2026
By Nuala Moran
No Comments
Mestag Therapeutics Ltd. has raised a $40 million round from existing investors as it completes final preparations for its lead program MST-0312 to enter clinical development in mid-2026. MST-0312 is a bispecific antibody aimed at the lymphotoxin-β receptor (LTBR), which is essential for the development of lymphoid tissues.
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Tinted Euro symbol
Newco news

Enodia jumps ahead in Sec61 targeting, adds Kezar’s program

March 16, 2026
By Brian Orelli
No Comments
Enodia Therapeutics Inc. was spun out of The Institut Pasteur by Argobio Studio based on the work of Caroline Demangel, co-founder of Enodia and head of the immunobiology and therapy unit at The Institut Pasteur. Demangel’s lab discovered the mechanism of action of mycolactone, a natural Sec61 inhibitor that causes Buruli ulcers.
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