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BioWorld - Tuesday, December 16, 2025
Home » Topics » Disease categories and therapies » Inflammatory

Inflammatory
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Ryoncil

Mesoblast prices pediatric stem cell treatment at $1.55 million

March 4, 2025
By Tamra Sami
Regenerative medicine company Mesoblast Ltd. is preparing to launch its allogeneic bone marrow-derived mesenchymal stromal cell (MSC) therapy, Ryoncil, (remestemcel-L), in March in the U.S. and has priced the treatment at roughly $1.55 million for a full course.
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Novartis adds Kyorin’s preclinical MRGPRX2 antagonist in $777M deal

March 4, 2025
By Tamra Sami
Kyorin Pharmaceutical Co. Ltd. has out-licensed its preclinical candidate, KRP-M223, and its back-up compounds to Novartis Pharma AG in a deal worth up to $777.5 million. Under the terms, Novartis gains an exclusive worldwide license to develop, manufacture and commercialize Kyorin-discovered KRP-M223.
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3D rendering of drug linked to antibody

Hummingbird migrates ADCs, tech to newco Callio’s $187M debut

March 4, 2025
By Marian (YoonJee) Chu
Antibody-drug conjugate (ADC)-focused Callio Therapeutics debuted on March 3 with the closing of a $187 million series A financing round based on cancer drug technology and assets in-licensed from Hummingbird Bioscience Pte Ltd.
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Microbiome illustration
Gastrointestinal

New microbiome-based therapy shows potent anti-inflammatory efficacy in models of IBD

Feb. 28, 2025
Researchers from CJ Bioscience Inc. presented the discovery and preclinical characterization of CJRB-201, a novel microbiome-based therapy for the treatment of inflammatory bowel disease (IBD).
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Ryoncil

Mesoblast prices pediatric stem cell treatment at $1.55 million

Feb. 27, 2025
By Tamra Sami
Regenerative medicine company Mesoblast Ltd. is preparing to launch its allogeneic bone marrow-derived mesenchymal stromal cell (MSC) therapy, Ryoncil, (remestemcel-L), in March in the U.S. and has priced the treatment at roughly $1.55 million for a full course.
Read More
Intestine
Gastrointestinal

ACSS2 as pro-inflammatory factor and therapeutic target in IBD

Feb. 27, 2025
Scientists from the Lebanese American University investigated the role of acetyl-CoA synthetase short chain family member 2 (ACSS2) in inflammatory bowel disease, including ulcerative colitis and Crohn’s disease.
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3D illustration of transparent human torso with close up of spinal cord

Qyuns’ QX-002N hits endpoints in ankylosing spondylitis trial

Feb. 25, 2025
By Tamra Sami
Qyuns Therapeutics Co. Ltd.’s monoclonal antibody targeting IL-17A, QX-002N, met both primary and secondary endpoints in a phase III trial in ankylosing spondylitis.
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Gastrointestinal system with ulcerative colitis.
Gastrointestinal

Targeting HMGCS2 is new approach in ulcerative colitis

Feb. 25, 2025
Researchers from The University of Edinburgh have presented data from a study that aimed to investigate the mechanisms behind intestinal stem cell (ISC) dysfunction in ulcerative colitis (UC).
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3d rendering of bispecific antibodies
Gastrointestinal

HXN-1002, a bispecific antibody simultaneously targeting α4β7 and TL1A

Feb. 24, 2025
At the recent 2025 congress of the European Crohn’s and Colitis Organisation, researchers from Helixon Therapeutics presented the discovery and preclinical characterization of HXN-1002, a bispecific antibody simultaneously targeting both α4β7 and TL1A that is being investigated as a potential treatment for inflammatory bowel disease.
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Inflammatory

Beijing Synthetic Vaccine Biosciences divulges new TLR8 agonists

Feb. 19, 2025
Beijing Synthetic Vaccine Biosciences Co. Ltd. has synthesized Toll-like receptor 8 (TLR8) agonists reported to be useful for the treatment of autoimmune disease, cancer, inflammatory disorders and viral infection.
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