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Home » Topics » Disease categories and therapies » Inflammatory

Inflammatory
Inflammatory RSS Feed RSS

Research lab illustration
Immune

Novel CCR6-selective antagonist advances in the immune-mediated disorders pipeline

May 29, 2024
C-C chemokine receptor type 6 (CCR6) regulates the migration and recruitment of T cells in inflammatory and immunological processes and, as part of the CCR6-CCL20 axis together with its exclusive binding molecule CCL20, plays a critical role in maintaining immunological homeostasis during inflammation and infection.
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Inflammatory

Transthera Biosciences discovers new NLRP3 inflammasome inhibitors

May 28, 2024
Transthera Biosciences Co. Ltd. has described NLRP3 inflammasome inhibitors reported to be useful for the treatment of autoimmune disease, inflammatory disorders and immunological disorders.
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Pipet, test tubes, chemical structure
Inflammatory

Recludix presents new orally available STAT3 inhibitors

May 27, 2024
A proprietary Src homology 2 (SH2) platform of integrated technologies was applied for the discovery of REX-7117 and REX-5376, two highly potent, selective and orally available SH2 domain-targeting STAT3 inhibitors.
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Woman applying skin cream to elbow
Dermatologic

ACLY inhibitors may be useful for treating psoriasis

May 27, 2024
Psoriasis is an inflammatory skin disease in which lipid metabolism is often dysregulated. ATP-citrate synthase (ACLY) is known to play a key role in lipid metabolism, but its involvement in psoriasis is not well understood.
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Inflammatory

Shanghai Shenshi Wise Technology describes new KCNA3 channel blockers

May 24, 2024
Shanghai Shenshi Wise Technology Co. Ltd. has identified potassium voltage-gated channel subfamily A member 3 (KCNA3) channel blockers reported to be useful for the treatment of inflammatory and immunological disorders.
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Handshake with DNA, molecules
Cancer

Degron collaborates with Takeda on molecular glue degraders

May 24, 2024
Degron Therapeutics Inc. has entered into a collaboration and exclusive license agreement with Takeda Pharmaceutical Co. Ltd. to discover and develop novel molecular glue degraders for multiple targets in oncology, neuroscience and inflammation.
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Close up of hand scratching arm with psoriasis patches
Biomarkers

BAG3 protein is present in serum from patients with psoriasis

May 16, 2024
Due to the systemic nature of psoriasis, there is high risk for progressive severe forms of the disease.
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Art concept for inflamed human tissue
Inflammatory

Aqilion targets PKCθ in new immunology project

May 14, 2024
Aqilion AB has expanded its pipeline through the nomination of protein kinase C θ (PKCθ) as the target of a new immunology project. The PKCθ kinase is believed to be centrally involved in the pathogenesis of T-cell-mediated inflammatory and autoimmune diseases.
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Antibodies

Obexelimab’s one-two punch in IgG4 hooks $200M for Zenas

May 7, 2024
By Randy Osborne
The bifunctional antibody approach continues to pay off for Zenas Biopharma Inc., which banked an upsized $200 million series C preferred stock financing led by SR One along with NEA, Norwest Venture Partners and Delos Capital. Enavate Sciences and Longitude Capital participated significantly as well.
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Coin inserted into Australian map

Australia investing AU$1.89B for new research, clinical trials

May 7, 2024
By Tamra Sami
The Australian government is investing AU$1.89 billion (US$1.25 billion) in what it is calling a “once-in-a generation transformation” of health and medical research in Australia with $1.4 billion tagged for new research for the Medical Research Future Fund.
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