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Home » Topics » Disease categories and therapies » Inflammatory

Inflammatory
Inflammatory RSS Feed RSS

Blood cells and bacteria
Infection

Broader sepsis insights gleaned from SARS-CoV-2-driven research

June 21, 2024
By Nuala Moran
New research has pinpointed gene signatures that determine what immune responses will be activated in the development of sepsis, pointing to novel targets and opening the way for the stratification of clinical trials and for patients to be treated on the basis of their immune response, rather than their symptoms.
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Inflammatory

Odyssey Therapeutics discovers new RIPK2 inhibitors

June 19, 2024
Odyssey Therapeutics Inc. has described receptor-interacting serine/threonine-protein kinase 2 (RIPK2; RIP-2) inhibitors reported to be useful for the treatment of autoimmune diseases, chronic granulomatous disease, neurodegeneration, inflammatory disorders and cancer.
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3D rendering of skin cells and elastin with collagen layer
Dermatologic

CXCR7 modulator IL-1512 reduces skin fibrosis in mice

June 18, 2024
Systemic sclerosis is an autoimmune disorder characterized by inflammation, vasculopathy and fibrosis, mainly affecting internal organs and the skin. There is still a lack of therapies for SSc-induced skin fibrosis.
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IBAT they can: Mirum’s volixibat wins in PBC, PSC validate hope

June 17, 2024
By Randy Osborne
Optimism on Wall Street proved wise and shares of Mirum Pharmaceuticals Inc. (NASDAQ:MIRM) rose accordingly to close June 17 at $33, up $7.08, or 27.3%, as the firm disclosed interim results from two phase IIb studies evaluating volixibat, an oral ileal bile acid transporter (IBAT) inhibitor, in patients with primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC). The drug proved its mettle in both liver biliary tract-stenosing indications, with no new safety signals turning up, Foster City, Calif.-based Mirum said.
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Microscope with beakers and flasks
Gastrointestinal

Enveda Biosciences raises financing to advance anti-inflammatory programs

June 17, 2024
Enveda Biosciences (Enveda Therapeutics Inc.) has announced a new series B2 financing round of $55 million. The drug discovery and development company uses artificial intelligence (AI)-powered technologies to translate nature into new medicines.
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Joint pain
Musculoskeletal

MRT-6160 shows promise in collagen-induced arthritis model

June 17, 2024
The immune cell restricted guanine nucleotide exchange factor (GEF) and scaffolding protein VAV1 plays a key role in mediating T-cell receptor (TCR) and B-cell receptor (BCR) activity and signaling.
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Inflammatory

Santa Ana Bio outlines precision immunology therapy pipeline

June 14, 2024
Santa Ana Bio Inc. has emerged from stealth with $168 million in combined series A and B funding and a focus on developing targeted therapies for patients with autoimmune and inflammatory diseases.
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Purple-tinted test tubes and dropper
Inflammatory

NKTR-0165 enhances Treg function, may be approach for chronic inflammatory diseases

June 14, 2024
At the ongoing EULAR meeting, Nektar Therapeutics Inc. presented the first preclinical data on its anti-TNFR2 agonist antibody – NKTR-0165 – for the potential treatment of autoimmune and chronic inflammatory diseases.
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Peter Emtage, CEO, Santa Ana Bio
Newco news

Favorable winds blow for Santa Ana Bio: $168M in hand

June 13, 2024
By Randy Osborne
Santa Ana Bio Inc. launched with combined series A and B rounds that pulled down $168 million for its precision immunology push in inflammatory diseases, with an aim of entering the clinic next year across several fronts.
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3D rendering of CAR T therapy in cell
Cancer

Acepodia’s antibody cell conjugation platform could disrupt CAR Ts

June 12, 2024
By Tamra Sami
Acepodia Inc.’s antibody cell conjugation platform could change the way CAR T-cell therapies are manufactured, clearing the way for an off-the-shelf model to treat numerous cancers that is safer and cheaper than current CAR Ts, Acepodia CEO Sonny Hsiao told BioWorld.
Read More
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