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Home » Topics » Disease categories and therapies » Inflammatory

Inflammatory
Inflammatory RSS Feed RSS

Deal handshake with coin, chart background

Aprilbio, Evommune strike $475M deal for autoinflammatory drug

June 21, 2024
By Marian (YoonJee) Chu
Aprilbio Co. Ltd. saw its stock surge 30% June 20 after announcing a potential $475 million (₩655.88 billion) deal with Evommune Inc. for autoimmune disease drug candidate APB-R3.
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Neutrophil and red blood cells
Inflammatory

Alivexis and Melodia sign license agreement for cathepsin C inhibitor MDI-0151

June 21, 2024
Alivexis Inc. and Melodia Therapeutics AG have entered into an exclusive license agreement for the worldwide development, manufacturing and commercialization of Alivexis’ MDI-0151, a novel cathepsin C inhibitor identified in Alivexis’ MOD-A discovery program.
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Liver anatomy with virus
Gastrointestinal

Ose reports preclinical results on IL-35 mRNA therapeutic for autoimmune hepatitis

June 21, 2024
Ose Immunotherapeutics SA has presented preclinical data on its mRNA therapeutic platform for the treatment of inflammatory and autoimmune disorders. The platform has been designed for the local delivery of mRNA into inflammatory tissue using lipid nanoparticles (LNPs). Interleukin-35 (IL-35) has been shown in preclinical studies to have a key role in controlling several immune-related disorders, including autoimmune diseases.
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Blood cells and bacteria
Infection

Broader sepsis insights gleaned from SARS-CoV-2-driven research

June 21, 2024
By Nuala Moran
New research has pinpointed gene signatures that determine what immune responses will be activated in the development of sepsis, pointing to novel targets and opening the way for the stratification of clinical trials and for patients to be treated on the basis of their immune response, rather than their symptoms.
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Inflammatory

Odyssey Therapeutics discovers new RIPK2 inhibitors

June 19, 2024
Odyssey Therapeutics Inc. has described receptor-interacting serine/threonine-protein kinase 2 (RIPK2; RIP-2) inhibitors reported to be useful for the treatment of autoimmune diseases, chronic granulomatous disease, neurodegeneration, inflammatory disorders and cancer.
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3D rendering of skin cells and elastin with collagen layer
Dermatologic

CXCR7 modulator IL-1512 reduces skin fibrosis in mice

June 18, 2024
Systemic sclerosis is an autoimmune disorder characterized by inflammation, vasculopathy and fibrosis, mainly affecting internal organs and the skin. There is still a lack of therapies for SSc-induced skin fibrosis.
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IBAT they can: Mirum’s volixibat wins in PBC, PSC validate hope

June 17, 2024
By Randy Osborne
Optimism on Wall Street proved wise and shares of Mirum Pharmaceuticals Inc. (NASDAQ:MIRM) rose accordingly to close June 17 at $33, up $7.08, or 27.3%, as the firm disclosed interim results from two phase IIb studies evaluating volixibat, an oral ileal bile acid transporter (IBAT) inhibitor, in patients with primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC). The drug proved its mettle in both liver biliary tract-stenosing indications, with no new safety signals turning up, Foster City, Calif.-based Mirum said.
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Microscope with beakers and flasks
Gastrointestinal

Enveda Biosciences raises financing to advance anti-inflammatory programs

June 17, 2024
Enveda Biosciences (Enveda Therapeutics Inc.) has announced a new series B2 financing round of $55 million. The drug discovery and development company uses artificial intelligence (AI)-powered technologies to translate nature into new medicines.
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Joint pain
Musculoskeletal

MRT-6160 shows promise in collagen-induced arthritis model

June 17, 2024
The immune cell restricted guanine nucleotide exchange factor (GEF) and scaffolding protein VAV1 plays a key role in mediating T-cell receptor (TCR) and B-cell receptor (BCR) activity and signaling.
Read More
Inflammatory

Santa Ana Bio outlines precision immunology therapy pipeline

June 14, 2024
Santa Ana Bio Inc. has emerged from stealth with $168 million in combined series A and B funding and a focus on developing targeted therapies for patients with autoimmune and inflammatory diseases.
Read More
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