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Home » Topics » Disease categories and therapies » Inflammatory

Inflammatory
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3D rendering of CAR T therapy in cell
Cancer

Acepodia’s antibody cell conjugation platform could disrupt CAR Ts

June 12, 2024
By Tamra Sami
Acepodia Inc.’s antibody cell conjugation platform could change the way CAR T-cell therapies are manufactured, clearing the way for an off-the-shelf model to treat numerous cancers that is safer and cheaper than current CAR Ts, Acepodia CEO Sonny Hsiao told BioWorld.
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Acepodia’s antibody cell conjugation platform could disrupt CAR Ts

June 11, 2024
By Tamra Sami

Acepodia Inc.’s antibody cell conjugation platform could change the way CAR T-cell therapies are manufactured, clearing the way for an off-the-shelf model to treat numerous cancers that is safer and cheaper than current CAR Ts, Acepodia CEO Sonny Hsiao told BioWorld.


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Respiratory

S1PR3 is target in acute respiratory distress syndrome

June 6, 2024
Excessive inflammatory response and endothelial barrier dysfunction are the two major pathophysiological changes in acute respiratory distress syndrome (ARDS). Sphingosine-1-phosphate S1P3 receptor (S1PR3) is a G protein-coupled receptor involved in the regulation of inflammation and vascular barrier function in some diseases, but its function in ARDS is not fully understood.
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Liver anatomy with virus

Delta wave cresting? Vir phase II combo data strong in hepatitis

June 5, 2024
By Randy Osborne
An expert in hepatitis delta virus said Vir Biotechnology Inc.’s phase II findings with the monoclonal antibody tobevibart and the small interfering ribonucleic acid elebsiran in chronic disease could lead to a “change [in] the entire care cascade and paradigm.” Shares of Vir (NASDAQ:VIR) ended June 5 at $12.66, up $2.08, or 19.7%, on the clinical news.
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Inflammatory

Insilico Medicine patents NLRP3 inflammasome inhibitors

May 30, 2024
Insilico Medicine Inc. has identified NLRP3 inflammasome inhibitors reported to be useful for the treatment of autoimmune and inflammatory disorders.
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Illustration of intestines with inflammation
Gastrointestinal

Targeting glutaminase reduces ECM synthesis and alleviates intestinal fibrosis

May 30, 2024
Researchers from Shanghai Jiao Tong University presented findings from a study that aimed to assess the metabolic landscape of intestinal fibrosis in Crohn’s disease.
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Research lab illustration
Immune

Novel CCR6-selective antagonist advances in the immune-mediated disorders pipeline

May 29, 2024
C-C chemokine receptor type 6 (CCR6) regulates the migration and recruitment of T cells in inflammatory and immunological processes and, as part of the CCR6-CCL20 axis together with its exclusive binding molecule CCL20, plays a critical role in maintaining immunological homeostasis during inflammation and infection.
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Inflammatory

Transthera Biosciences discovers new NLRP3 inflammasome inhibitors

May 28, 2024
Transthera Biosciences Co. Ltd. has described NLRP3 inflammasome inhibitors reported to be useful for the treatment of autoimmune disease, inflammatory disorders and immunological disorders.
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Pipet, test tubes, chemical structure
Inflammatory

Recludix presents new orally available STAT3 inhibitors

May 27, 2024
A proprietary Src homology 2 (SH2) platform of integrated technologies was applied for the discovery of REX-7117 and REX-5376, two highly potent, selective and orally available SH2 domain-targeting STAT3 inhibitors.
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Woman applying skin cream to elbow
Dermatologic

ACLY inhibitors may be useful for treating psoriasis

May 27, 2024
Psoriasis is an inflammatory skin disease in which lipid metabolism is often dysregulated. ATP-citrate synthase (ACLY) is known to play a key role in lipid metabolism, but its involvement in psoriasis is not well understood.
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