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Home » Topics » Disease categories and therapies » Inflammatory

Inflammatory
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Dr. Widjaja viewing experimental data on the computer
Aging

Stop interleukin-11 to age better and live longer

July 26, 2024
By Mar de Miguel
Increased life expectancy also comes with age-related diseases. But what causes one to age? Although there is no single answer, scientists at Duke-National University of Singapore have shown in mice that interleukin-11 (IL-11) promoted aging. Blocking it improved health and lifespan.
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Inflammatory

Astrazeneca and Mitsubishi Tanabe Pharma jointly develop NLRP3 inflammasome inhibitors

July 24, 2024
A joint Astrazeneca AB and Mitsubishi Tanabe Pharma Corp. patent details NLRP3 inflammasome inhibitors reported to be useful for the treatment of liver, autoimmune and inflammatory bowel disease, inflammation, respiratory, cardiovascular and renal disorders.
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Inflammatory

Apichope Pharmaceutical and collaborators patent GPR84 antagonists

July 24, 2024
Apichope Bio Pharmaceutical Co. Ltd., Apichope Pharmaceutical Co. Ltd., Guangzhou Lianrui Pharmaceutical Co. Ltd. and Guangzhou Runlin Pharmaceutical Technology Co. Ltd. have jointly patented tricyclic compounds acting as G-protein coupled receptor 84 (GPR84) antagonists.
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Inflammatory

Roche patent describes new SIK inhibitors

July 24, 2024
F. Hoffmann-La Roche Ltd. and Hoffmann-La Roche Inc. have synthesized new benzimidazole derivatives acting as serine/threonine-protein kinase SIK inhibitors.
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Dr. Widjaja viewing experimental data on the computer
Aging

Stop interleukin-11 to age better and live longer

July 24, 2024
By Mar de Miguel
Increased life expectancy also comes with age-related diseases. But what causes one to age? Although there is no single answer, scientists at Duke-National University of Singapore (NUS) have shown in mice that interleukin-11 (IL-11) promoted aging. Blocking it improved health and lifespan.
Read More
Inflammatory

Immunophage Biomedical divulges new MIF inhibitors

July 23, 2024
Immunophage Biomedical Co. Ltd. has synthesized macrophage migration inhibitory factor (MIF) inhibitors reported to be useful for the treatment of cancer and inflammation.
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Aging

Immunopeptide supplementation restores immune function in aged mice

July 23, 2024
Age-related inflammation, also known as inflammaging, refers to low-grade chronic damage caused by increased inflammation linked to immunosenescence with impact at molecular, cellular and tissue levels. Aging amplifies the inflammatory response and increases neutrophil, monocyte and leukocyte trafficking in models of inflammation.
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Neurology/psychiatric

MK2 inhibitor protects murine microglial cells from neuroinflammation

July 19, 2024
Cigarette smoke, the main cause of chronic obstructive lung disease, is considered a significant contributor of neuroinflammation, potentially leading to cognitive impairment and neurodegeneration. About 61% of individuals with chronic obstructive pulmonary disease have neurocognitive dysfunction.
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Fruit fly muscles showing how well mitochondria produce energy
Infection

Infection and brain neuroinflammation weaken muscles

July 19, 2024
By Mar de Miguel
Muscle fatigue associated with brain inflammation could be prevented by modulating certain cytokines. Researchers at Washington University in St. Louis (WUSTL) have studied inflammation in the CNS in infection models of Escherichia coli, SARS-CoV-2 and amyloid-β toxicity, unveiling its impact on motor function, the role of IL-6 in this process and how to mitigate it in chronic disease.
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Kidney disease illustration

Vivoryon eyes phase III after kidney win with varoglutamstat

July 18, 2024
By Randy Osborne
About four months after varoglutamstat failed in Alzheimer’s disease, Vivoryon Therapeutics NV disclosed data from the Viviad phase IIb study with the same compound in kidney disease that provided cause for hope – and Anne Doering, chief financial officer, said the new data “reinforce our strategic shift.”
Read More
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