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Home » Topics » Disease categories and therapies » Inflammatory

Inflammatory
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Inflammatory

Vicore Pharma synthesizes AT2 receptor agonists

Aug. 8, 2024
Vicore Pharma AB has identified compounds acting as angiotensin AT2 receptor (AGTR2) agonists reported to be useful for the treatment of fibrosis, heart failure, pulmonary hypertension, respiratory tract infection, myocardial infarction, pre-eclampsia, autoimmune and chronic kidney disease.
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Person holding knee, joint pain

Levicept cites ‘truly exceptional’ data in osteoarthritis trial

Aug. 6, 2024
By Nuala Moran
Levicept Ltd. is scoping the options for phase III development after reporting positive results from its phase II trial of LEVI-04 in the treatment of pain caused by osteoarthritis of the knee. The full data are yet to be published, but the company said the potentially first-in-class neurotrophin-3 inhibitor demonstrated significant differences from placebo, with a mean reduction in pain score from baseline of more than 50%, for the three doses tested.
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Obesity, fat cell research concept image
Inflammatory

Zyversa selects lead indication for ASC inhibitor IC-100

Aug. 1, 2024
Zyversa Therapeutics Inc. announced it has selected obesity and its related metabolic complications as the lead indication for its ASC protein inhibitor IC-100. One consequence of high weight is chronic inflammation, which increases the risk of multiple metabolic and cardiovascular disorders.
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Hands holding holographic intestine
Inflammatory

Ensho debuts to target gut inflammation with oral α4β7 inhibitors

July 31, 2024
By Marian (YoonJee) Chu
Ensho Therapeutics Inc. launched in July after licensing a pipeline of four oral α4β7 inhibitors for inflammatory and gastrointestinal disorders, including inflammatory bowel disease (IBD), from EA Pharma Co. Ltd. “Millions of people worldwide are living with IBD,” Ensho founder, president and executive chair Neena Bitritto-Garg recently told BioWorld, “and while there are a number of approved medications to address the symptoms of IBD, it remains a difficult-to-treat disease with high relapse rates for a considerable proportion of patients.”
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Inflammatory

Forward Therapeutics discovers TNF-α production inhibitors

July 31, 2024
Forward Therapeutics Inc. has disclosed TNF-α production inhibitors reported to be useful for the treatment of inflammation and autoimmune disorders.
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Art concept for inflamed human tissue
Inflammatory

Grant funds research into microproteins as inflammation targets

July 31, 2024
Associate professor Lena Ho from Duke-NUS Medical School has been awarded US$1.85 million to further her team’s research.
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Hands holding holographic intestine
Newco news

Ensho debuts to target gut inflammation with oral α4β7 inhibitors

July 30, 2024
By Marian (YoonJee) Chu
Ensho Therapeutics Inc. launched in July after licensing a pipeline of four oral α4β7 inhibitors for inflammatory and gastrointestinal disorders, including inflammatory bowel disease (IBD), from EA Pharma Co. Ltd. “Millions of people worldwide are living with IBD,” Ensho founder, president and executive chair Neena Bitritto-Garg recently told BioWorld, “and while there are a number of approved medications to address the symptoms of IBD, it remains a difficult-to-treat disease with high relapse rates for a considerable proportion of patients.”
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Stick to TYK2? Ventyx says no after miss in mid-stage Crohn’s bid

July 29, 2024
By Randy Osborne
Another failure with allosteric tyrosine kinase 2 (TYK2) inhibitor VTX-958 put an end to internal work with the compound, and shares of Ventyx Biosciences Inc. (NASDAQ:VTYX) fell July 29 to $2.24, down 71 cents or 24%, after the firm disclosed results from the phase II, 109-subject trial in moderately to severely active Crohn’s disease (CD).
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Hands holding holographic intestine
Newco news

Ensho debuts to target gut inflammation with oral α4β7 inhibitors

July 26, 2024
By Marian (YoonJee) Chu
Ensho Therapeutics Inc. launched in July after licensing a pipeline of four oral α4β7 inhibitors for inflammatory and gastrointestinal disorders, including inflammatory bowel disease (IBD), from EA Pharma Co. Ltd. “Millions of people worldwide are living with IBD,” Ensho founder, president and executive chair Neena Bitritto-Garg recently told BioWorld, “and while there are a number of approved medications to address the symptoms of IBD, it remains a difficult-to-treat disease with high relapse rates for a considerable proportion of patients.”
Read More
Dr. Widjaja viewing experimental data on the computer
Aging

Stop interleukin-11 to age better and live longer

July 26, 2024
By Mar de Miguel
Increased life expectancy also comes with age-related diseases. But what causes one to age? Although there is no single answer, scientists at Duke-National University of Singapore have shown in mice that interleukin-11 (IL-11) promoted aging. Blocking it improved health and lifespan.
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