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Home » Topics » Disease categories and therapies » Inflammatory

Inflammatory
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Inflammatory

Shenzhen Zhongge Biotechnology describes new IRAK-4 inhibitors

Aug. 20, 2024
Shenzhen Zhongge Biotechnology Co. Ltd. has identified interleukin-1 receptor-associated kinase 4 (IRAK-4) inhibitors and derived PROTAC compounds reported to be useful for the treatment of autoimmune disorders, inflammatory disorders, cancer, transplant rejection and more.
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Drug R&D concept image.
Cancer

Cumulus Oncology licenses small molecules from GPR68 drug discovery project with Leadxpro

Aug. 20, 2024
Cumulus Oncology Ltd. has announced key milestones, in partnership with collaborator Leadxpro AG, in the companies’ protein structure-driven GPR68 drug discovery project.
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Test tubes, dropper and capsules
Inflammatory

Immunesensor Therapeutics’ cGAS inhibitor to enter clinic in Australia

Aug. 19, 2024
Immunesensor Therapeutics Inc. has received Human Research Ethics Committee (HREC) approval and clinical trial notification (CTN) clearance by Australia’s Therapeutic Goods Administration (TGA) to initiate a phase I study of IMSB-301, a novel, orally available small-molecule cGAS inhibitor that is being developed for the treatment of inflammatory and autoimmune diseases.
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Blue dollar sign on white background
Dermatologic

Kalm Therapeutics closes seed round

Aug. 16, 2024
Kalm Therapeutics Inc. disclosed a $700,000 oversubscribed closing of its seed round, which will be used to complete regulatory activities outlined in Kalm’s pre-IND meeting with the U.S. FDA, fund personnel and transfer the company’s patch production to a manufacturer.
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Doctor pointing at liver
Gastrointestinal

MID1 involved in liver injury by promoting immune infiltration

Aug. 14, 2024
Hepatic ischemia-reperfusion injury (HIRI) is a common leading cause of liver injury and is associated with several clinical conditions, including liver transplantation, liver resection surgeries and cancer, among others.
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Liver over digital lens background
Gastrointestinal

New PTP1B inhibitor ameliorates liver fibrosis in mice

Aug. 13, 2024
Liver fibrosis still lacks effective therapy; hepatic stellate cells (HSCs) are the primary fibrogenic cell type activated during liver injury. To date, almost half of the drugs used for liver treatment are natural product derivatives.
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Man holding raised arm with illustrated overlay of nerves
Inflammatory

COX-2 inhibitor AAT-076 ameliorates neuropathic pain

Aug. 12, 2024
AAT-076 was tested in the preclinical setting for its analgesic potential in COX-1 and COX-2 assays, as well as in in vivo rat models of air pouch inflammation, adjuvant-induced arthritis and neuropathic pain models. The compound was selected as a candidate analgesic compound due to its effective COX-2 inhibition within the central nervous system.
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Art concept for inflammation in the intestines
Gastrointestinal

TRX-103 cleared for clinic in treatment-refractory Crohn’s disease

Aug. 9, 2024
Tr1x Inc. has announced that the FDA has cleared its IND application for its engineered Tr1 Treg cell therapy TRX-103 for treatment-refractory Crohn’s disease.
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Inflammatory

Shanghai Meiyue Biotech Development presents new MAPK p38 inhibitors

Aug. 8, 2024
Shanghai Meiyue Biotech Development Co. Ltd. has discovered MAPK p38 inhibitors reported to be useful for the treatment of arthritis, psoriasis, systemic lupus erythematosus, diabetes, cancer, atherosclerosis and Alzheimer's disease.
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Inflammatory

Vicore Pharma synthesizes AT2 receptor agonists

Aug. 8, 2024
Vicore Pharma AB has identified compounds acting as angiotensin AT2 receptor (AGTR2) agonists reported to be useful for the treatment of fibrosis, heart failure, pulmonary hypertension, respiratory tract infection, myocardial infarction, pre-eclampsia, autoimmune and chronic kidney disease.
Read More
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