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Home » Topics » Disease categories and therapies » Inflammatory

Inflammatory
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Inflammatory

Shanghai Yidi Biotechnology discovers PDE4B2 and PDE4D2 inhibitors

Nov. 6, 2024
Shanghai Yidi Biotechnology Co. Ltd. has patented dihydrothienopyrimidine compounds acting as phosphodiesterase PDE4B2 and/or PDE4D2 inhibitors reported to be useful for the treatment of autoimmune, metabolic diseases, neurological and inflammatory disorders.
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Monoclonal antibody illustration
Inflammatory

Hifibio Therapeutics’ BTLA agonist antibody gains US IND clearance

Nov. 5, 2024
Hifibio Therapeutics Inc. has gained IND clearance from the FDA for HFB-200604, a potentially best-in-class BTLA agonist monoclonal antibody for inflammatory and immunology diseases.
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Inflammatory

Biogen patents TYK2 inhibitors for inflammatory disorders

Oct. 31, 2024
Biogen Inc. has identified non-receptor tyrosine-protein kinase TYK2 inhibitors reported to be useful for the treatment of cancer, autoimmune disease, cardiovascular disorders, fibrosis, inflammatory disorders, liver diseases, pain and neurodegeneration, among others.
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Inflammatory

Shanghai Yidi Biotechnology describes new PDE4B2 and PDE4D2 inhibitors

Oct. 30, 2024
Shanghai Yidi Biotechnology Co. Ltd. has identified dihydrothienopyrimidine compounds acting as phosphodiesterase PDE4B2 and/or phosphodiesterase PDE4D2 inhibitors reported to be useful for the treatment of autoimmune disorders, metabolic diseases, neurological diseases and inflammatory disorders.
Read More
Art concept for molecular glue degradation

Monte Rosa, Novartis have one in VAV1, sign $2.1B pact

Oct. 28, 2024
By Randy Osborne
An old target that found new life at Monte Rosa Therapeutics Inc. has become the subject of a sizeable deal between the company and Novartis AG, as the pair set about developing molecular glue degraders (MGDs). Shares of Monte Rosa (NASDAQ:GLUE) closed Oct. 28 at $9.48, up $4.59, or 93.9%, on word of the Boston-based firm’s deal with Novartis to advance VAV1 MGDs, including MRT-6160, a prospect undergoing a phase I single ascending dose/multiple ascending dose study in healthy volunteers for immune-mediated conditions.
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Inflammatory

LG Chem prepares new autotaxin inhibitors

Oct. 22, 2024
Work at LG Chem Ltd. has led to the development of novel benzimidazolone derivatives acting as ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (ENPP2; autotaxin) inhibitors potentially useful for the treatment of cancer and fibrosis.
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Abstract molecular structure art
Gastrointestinal

Novel bivalent peptide shows efficacy in DSS-induced colitis model

Oct. 22, 2024
Researchers from Phoenixlab, The Scripps Research Institute and affiliated organizations presented the discovery of a novel bivalent protease-activated receptor PAR1- and PAR3-derived peptide, named biparetide, being developed for the treatment of inflammatory bowel disease (IBD).
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Illustration of cancer in the pancreas
Cancer

Repetitive RNAs change cellular states in pancreatic cancer

Oct. 22, 2024
By Mar de Miguel
Repeated RNA elements have a virus-like behavior in the cells that express them. Furthermore, they could confer a novel mode of tumor expansion based on changes in cellular states. “About 10 years ago, we had identified that these repetitive elements were highly expressed in pancreas cancer,” co-senior author David Ting, associate professor of medicine and assistant physician at the Mass General Cancer Center at Harvard Medical School, told BioWorld.
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Hands holding holographic intestine
Gastrointestinal

SPY-003, an extended half-life MAb with twice-a-year projected human maintenance dosing

Oct. 18, 2024
Paragon Therapeutics Inc. and Spyre Therapeutics Inc. jointly presented preclinical data for the novel extended half-life humanized anti-IL-23 monoclonal antibody (MAb), SPY-003, being developed for the treatment of inflammatory bowel disease (IBD).
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Lab glassware and antibodies art concept
Gastrointestinal

XmAb-942, a novel anti-TL1A MAb with extended half-life and improved potency

Oct. 17, 2024
Researchers from Xencor Inc. presented the discovery and preclinical characterization of XmAb-942, a novel high-affinity anti-TL1A monoclonal antibody (MAb) being developed for the treatment of inflammatory bowel disease (IBD).
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