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BioWorld - Sunday, June 22, 2025
Home » Topics » Disease categories and therapies » Inflammatory

Inflammatory
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Inflammatory

NLRP3 inflammasome inhibitors disclosed in Merck Sharp & Dohme patent

Dec. 20, 2024
Merck Sharp & Dohme LLC has divulged NLRP3 inflammasome inhibitors reported to be useful for the treatment of atherosclerosis, nonalcoholic or metabolic dysfunction-associated steatohepatitis (NASH/MASH), neuroinflammation, inflammatory skin, inflammatory joint and autoimmune disease, Alzheimer’s disease and Parkinson’s disease, among others.
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Inflammatory

Deepcure discovers oral STAT6 inhibitors for type 2 inflammatory diseases

Dec. 20, 2024
Deepcure Inc. has discovered potent, selective oral small-molecule inhibitors of STAT6. These next-generation STAT6 inhibitors have demonstrated promising oral bioavailability, cell permeability and metabolic stability, and do not target STAT6 for degradation.
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Inflammatory

ATYR-0101 exerts anti-fibrotic activity in lung and kidney

Dec. 20, 2024
Researchers from Atyr Pharma Inc. presented preclinical efficacy data of ATYR-0101, a potential therapeutic biologic based on a domain appended to aspartyl-tRNA synthetase (DARS) in models of lung and kidney fibrosis. By targeting latent-transforming growth factor beta-binding protein 1 (LTBP-1), ATYR-0101 induced apoptosis in myofibroblasts which play a central role in fibrosis and tissue remodeling.
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3D illustration of mesenchymal stem cells

Mesoblast scores first US nod for mesenchymal stromal cell therapy

Dec. 19, 2024
By Tamra Sami
Regenerative medicine company Mesoblast Ltd. received an early Christmas present from the FDA for approval of its allogeneic bone marrow-derived mesenchymal stromal cell (MSC) therapy, Ryoncil (remestemcel-L), for steroid-refractory acute graft-vs.-host disease (SR-aGvHD) in children 2 months and older, including adolescents.
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Promise Bio founders
Immune

Promise Bio raises $8.3M for immune-mediated diseases platform

Dec. 19, 2024
By Shani Alexander
Promise Bio Ltd. emerged from stealth with $8.3 million in seed investment for its precision medicine platform, which addresses immune-mediated diseases. The funding will be used to accelerate the development of the company’s technology that analyzes proteins and their post-translational modifications to predict the treatment responses of patients with immune-mediated diseases.
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Inflammatory

Insilico Medicine patents new NLRP3 inflammasome inhibitors

Dec. 18, 2024
Insilico Medicine Inc. has disclosed NLRP3 inflammasome inhibitors reported to be useful for the treatment of autoimmune and inflammatory disorders.
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Man measuring waist

Caliway’s CBL-514 meets endpoints in reducing abdominal fat

Dec. 17, 2024
By Tamra Sami
Caliway Biopharmaceuticals’ lipolysis candidate, CBL-514, met all the primary and secondary efficacy endpoints in a phase IIb study for subcutaneous fat reduction, paving the way for the company to begin a global pivotal phase III study in 2025.
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T cells

Candid, Epimab ink $1B T-cell engager deal in autoimmune disease

Dec. 17, 2024
By Tamra Sami
Candid Therapeutics Inc. and Epimab Biotherapeutics Inc. have entered a $1 billion research collaboration to discover and develop novel T-cell engager candidates for autoimmune indications.
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Concept of business partnership

Relation inks two GSK deals tackling osteoarthritis, fibrotic disease

Dec. 12, 2024
By Nuala Moran
Relation Therapeutics Ltd. has delivered the first commercial validation of its combined wet lab/in silico platform for homing in on disease-related genes in the thick of the genome, signing two collaboration agreements with GSK plc, with a potential value of $200 million per target.
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Man measuring waist

Caliway’s CBL-514 meets endpoints in reducing abdominal fat

Dec. 12, 2024
By Tamra Sami
Caliway Biopharmaceuticals’ lipolysis candidate, CBL-514, met all the primary and secondary efficacy endpoints in a phase IIb study for subcutaneous fat reduction, paving the way for the company to begin a global pivotal phase III study in 2025.
Read More
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