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Home » Topics » Disease categories and therapies » Inflammatory

Inflammatory
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Inflammatory

TGM2 inhibitors described in Aston University patent

Jan. 29, 2025
Work at Aston University has led to the identification of tissue transglutaminase (TGM2) inhibitors potentially useful for the treatment of fibrosis, thrombosis, cancer, AIDS, inflammation, transplant rejection, neurodegenerative and autoimmune diseases, among others.
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Artery and plaque
Cardiovascular

Reducing AnxA8 expression in endothelial cells delays progression of atherosclerosis

Jan. 29, 2025
Researchers from Fundación Jiménez Díaz and affiliated organizations have published data from a study that aimed to identify new genes involved in the progression of atherosclerosis, a chronic multifactorial inflammatory disease characterized by the accumulation of lipids and leukocytes within the arterial wall.
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Red wooden approved stamp

TGA clears CSL’s garadacimab to prevent hereditary angioedema

Jan. 28, 2025
By Tamra Sami
Australia’s Therapeutic Goods Administration (TGA) has approved CSL Ltd.’s Andembry (garadacimab) for preventing recurrent hereditary angioedema attacks, marking the first global approval for the drug that was discovered and developed in Australia by CSL scientists.
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Handshake dollar sign

AB2 Bio, Nippon Shinyaku in $686M deal for IL-18 drug tadekinig

Jan. 27, 2025
By Nuala Moran
Inflammatory diseases specialist AB2 Bio Ltd. has signed a potential $686 million U.S. commercialization deal for its interleukin-18 neutralizing drug tadekinig. The agreement with Japanese pharma company Nippon Shinyaku Co. Ltd. includes an initial payment of $6 million, with a further $30 million due later this year.
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Closeup of red eye
Immune

AMG-487 dampens inflammation in autoimmune uveitis model

Jan. 24, 2025
Researchers from Sun Yat-Sen University and affiliated organizations presented data from a study that aimed to investigate mechanisms by which the CXC chemokine receptor 3 (CXCR3) antagonist, AMG-487, acts on autoimmune uveitis.
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Illustration of human body composed of molecules
Inflammatory

LXZ-42 has anti-inflammatory activity, 90% oral bioavailability

Jan. 24, 2025
Researchers from Beijing Institute of Technology (BIT) and affiliated organizations presented the discovery and preclinical characterization of novel soluble epoxide hydrolase 2 (sEH) inhibitors as candidates for the treatment of inflammatory disorders.
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Inflammatory

Korean researchers discover new TYK2 inhibitors

Jan. 21, 2025
Azothbio Inc. and Daegu-Gyeongbuk Medical Innovation Foundation have described non-receptor tyrosine-protein kinase TYK2 inhibitors reported to be useful for the treatment of autoimmune disease, cancer, endocrine, inflammatory and neurological disorders.
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Inflammatory

HDAC6 inhibitors detailed in Augustine Therapeutics patent

Jan. 17, 2025
Augustine Therapeutics NV has synthesized new heteroaryl-amine compounds acting as histone deacetylase 6 (HDAC6) inhibitors and thus reported to be useful for the treatment of inflammation, autoimmune disease, cancer, neurodegeneration, pain, neuropathy, psychiatric and cardiovascular disorders.
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Nephrology

MDL-800 suppresses SIRT6-mediated inflammation and renal damage in models of CaOx nephrocalcinosis

Jan. 17, 2025
Kidney stones are largely composed of calcium oxalate (CaOx), which can cause serious renal inflammation and damage to renal tubular epithelial cells, with the CaOx crystals gradually accumulating and leading to CaOx nephrocalcinosis.
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Dermatologic

Targeting GluK2 combats mast cell activation and skin inflammation

Jan. 15, 2025
A recent study published in Science Translational Medicine has examined a new approach to address inflammatory skin diseases, such as dermatitis and rosacea, by focusing on a specific glutamate receptor in mast cells.
Read More
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