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Home » Topics » Disease categories and therapies » Inflammatory

Inflammatory
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Inflammatory

Greenstone Biosciences discloses dihydroartemisinin derivatives for fibrosis

Feb. 10, 2025
Work at Greenstone Biosciences Inc. has led to the identification of dihydroartemisinin derivatives reported to be useful for the treatment of fibrosis.
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Neurology/psychiatric

Downregulation of microglia NLRC5 protects mice from post-stroke neuroinflammation

Feb. 6, 2025
Researchers from Nanjing Drum Tower Hospital reported findings from their evaluation of the role of NLR family CARD domain containing 5 (NLRC5) in post-stroke neuroinflammation. Immunofluorescence staining of mouse brains revealed that NLRC5 was mainly expressed in microglia.
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Red wooden approved stamp

TGA clears CSL’s garadacimab to prevent hereditary angioedema

Feb. 4, 2025
By Tamra Sami
Australia’s Therapeutic Goods Administration (TGA) has approved CSL Ltd.’s Andembry (garadacimab) for preventing recurrent hereditary angioedema attacks, marking the first global approval for the drug that was discovered and developed in Australia by CSL scientists.
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Handshake dollar sign

AB2 Bio, Nippon Shinyaku in $686M deal for IL-18 drug tadekinig

Feb. 4, 2025
By Nuala Moran
Inflammatory diseases specialist AB2 Bio Ltd. has signed a potential $686 million U.S. commercialization deal for its interleukin-18 neutralizing drug tadekinig. The agreement with Japanese pharma company Nippon Shinyaku Co. Ltd. includes an initial payment of $6 million, with a further $30 million due later this year.
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Heart and lungs
Respiratory

STAT6, new therapeutic target for obstructive sleep apnea-related pulmonary hypertension

Feb. 4, 2025
One potentially serious complication of obstructive sleep apnea (OSA) is pulmonary hypertension (PH). Based on previous research that revealed involvement of perivascular immune and inflammatory responses in regulation of vascular remodeling and PH processing, researchers from Fudan University investigated the immunologic factors linked to OSA-induced PH.
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Inflammatory

Chinese researchers describe JX-06’s effects in multiple organ injury

Jan. 30, 2025
Multiple organ dysfunction syndrome is a life-threatening condition derived from heat stress or sepsis, among other conditions, that can lead to irreversible organ damage and death if left untreated. Gasdermin (GSDMD) is an executor protein that causes cell lysis, facilitates the release of inflammatory mediators and is involved in pyroptosis, apoptosis and necroptosis processes leading to inflammatory cell death or PANoptosis.
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Inflammatory

Nitric oxide scavengers detailed in Omniamed and Pohang University patent

Jan. 29, 2025
Omniamed Co. Ltd. and Pohang University of Science & Technology have patented compounds acting as nitric oxide (NO) scavengers and reported to be useful for the treatment of cancer, allergy, obesity, myelofibrosis, autoimmune diseases, inflammatory, cardiovascular and neurological disorders, among others.
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Inflammatory

TGM2 inhibitors described in Aston University patent

Jan. 29, 2025
Work at Aston University has led to the identification of tissue transglutaminase (TGM2) inhibitors potentially useful for the treatment of fibrosis, thrombosis, cancer, AIDS, inflammation, transplant rejection, neurodegenerative and autoimmune diseases, among others.
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Artery and plaque
Cardiovascular

Reducing AnxA8 expression in endothelial cells delays progression of atherosclerosis

Jan. 29, 2025
Researchers from Fundación Jiménez Díaz and affiliated organizations have published data from a study that aimed to identify new genes involved in the progression of atherosclerosis, a chronic multifactorial inflammatory disease characterized by the accumulation of lipids and leukocytes within the arterial wall.
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Red wooden approved stamp

TGA clears CSL’s garadacimab to prevent hereditary angioedema

Jan. 28, 2025
By Tamra Sami
Australia’s Therapeutic Goods Administration (TGA) has approved CSL Ltd.’s Andembry (garadacimab) for preventing recurrent hereditary angioedema attacks, marking the first global approval for the drug that was discovered and developed in Australia by CSL scientists.
Read More
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