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Home » Topics » Disease categories and therapies » Inflammatory

Inflammatory
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Connecting puzzle pieces
Inflammatory

STAT6 stat sig? Kaken, J&J $1.2B-plus deal adds oomph to space

Jan. 2, 2025
By Randy Osborne
Kaken Pharmaceutical Co. Ltd.’s license agreement with Johnson & Johnson (J&J) for signal transducer and activator of transcription (STAT)6 inhibitor KP-723 could presage further deals in STAT6, where a number of developers are active. Kaken’s arrangement with J&J involves the global development, manufacturing and sale of KP-723, which has reached the preclinical stage. Tokyo-based Kaken will take the drug through phase I trials, after which J&J takes over.
Read More
Connecting puzzle pieces

STAT6 stat sig? Kaken, J&J $1.2B-plus deal adds oomph to space

Dec. 31, 2024
By Randy Osborne
Kaken Pharmaceutical Co. Ltd.’s license agreement with Johnson & Johnson (J&J) for signal transducer and activator of transcription (STAT)6 inhibitor KP-723 could presage further deals in STAT6, where a number of developers are active. Kaken’s arrangement with J&J involves the global development, manufacturing and sale of KP-723, which has reached the preclinical stage. Tokyo-based Kaken will take the drug through phase I trials, after which J&J takes over.
Read More

Certa expands GPR68 platform via acquisition of Occurx

Dec. 31, 2024
By Tamra Sami
Certa Therapeutics Pty Ltd. has acquired Occurx Pty Ltd. in a move to strengthen its pipeline to target multiple fibrotic diseases as both companies share a focus on targeting GPR68, a defined G protein-coupled receptor (GPCR) receptor that mediates signaling pathways associated with inflammation and fibrosis and is thought to be a master switch of fibrosis.
Read More
Children in classroom wearing masks
Biomarkers

Rare BTNL8 variants associated with altered intestinal permeability are enriched in MIS-C patients

Dec. 31, 2024
Multisystem inflammatory syndrome in children (MIS-C) is a rare and severe condition following SARS-CoV-2 infection associated with intestinal manifestations. The most common clinical features include fever, abdominal pain, rash, myocardial dysfunction and elevated inflammatory biomarkers.
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Inflammatory

AM Sciences patent describes LPAR1 antagonists

Dec. 30, 2024
AM Sciences Inc. has reported compounds acting as lysophosphatidic acid receptor 1 (LPAR1; EDG2) antagonists described as potentially useful for the treatment of fibrosis.
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Inflammatory

NLRP3 inflammasome inhibitors detailed in Merck Sharp & Dohme patent

Dec. 30, 2024
Merck Sharp & Dohme LLC has patented new 5,6 saturated bicyclic heterocyles acting as NLRP3 inflammasome inhibitors potentially useful for the treatment of atherosclerosis, metabolic dysfunction-associated steatohepatitis (MASH), neuroinflammation, inflammatory skin, inflammatory joint and autoimmune disease, Alzheimer’s and Parkinson’s disease, among others.
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Year in review 2024 - Europe funding

European VC improves in 2024, driven by ADCs and CNS, inflammatory drugs

Dec. 27, 2024
By Nuala Moran
After the funding feast sparked by the pandemic, European biotech has emerged from the famine that followed, with venture capital raised this year finally exceeding the 2020 total.After the funding feast sparked by the pandemic, European biotech has emerged from the famine that followed, with venture capital raised this year finally exceeding the 2020 total.
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Certa expands GPR68 platform via acquisition of Occurx

Dec. 27, 2024
By Tamra Sami
Certa Therapeutics Pty Ltd. has acquired Occurx Pty Ltd. in a move to strengthen its pipeline to target multiple fibrotic diseases as both companies share a focus on targeting GPR68, a defined G protein-coupled receptor (GPCR) receptor that mediates signaling pathways associated with inflammation and fibrosis and is thought to be a master switch of fibrosis.
Read More
Connecting puzzle pieces

STAT6 stat sig? Kaken, J&J $1.2B-plus deal adds oomph to space

Dec. 27, 2024
By Randy Osborne
Kaken Pharmaceutical Co. Ltd.’s license agreement with Johnson & Johnson (J&J) for signal transducer and activator of transcription (STAT)6 inhibitor KP-723 could presage further deals in STAT6, where a number of developers are active. Kaken’s arrangement with J&J involves the global development, manufacturing and sale of KP-723, which has reached the preclinical stage. Tokyo-based Kaken will take the drug through phase I trials, after which J&J takes over.
Read More
Skin irritation on hands
Inflammatory

Kaken licenses STAT6 program to J&J

Dec. 27, 2024
Kaken Pharmaceutical Co. Ltd. and Johnson & Johnson (J&J) have entered into a license agreement for the global development, manufacturing and commercialization of a STAT6 program for autoimmune and allergic diseases, including atopic dermatitis (AD), developed by Kaken.
Read More
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