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Home » Topics » Disease categories and therapies » Inflammatory

Inflammatory
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Doctor pointing at liver

BIX 2024: From graveyard to breakthrough, MASH candidates on rise

July 16, 2024
By Marian (YoonJee) Chu
Nonalcoholic steatohepatitis was renamed, for the first time in 34 years, to metabolic dysfunction associated steatohepatitis (MASH), but a name change is far from being the biggest development in the field, according to experts at Bioplus Interphex (BIX) Korea 2024.
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Microglia and myelin
Neurology/psychiatric

BD2 inhibitor ABBV-744 demonstrates antineuroinflammatory effects in vivo

July 12, 2024
Researchers from the Chinese Academy of Sciences evaluated the highly potent and selective inhibitor of the second bromodomain (BD2) of the bromodomain and extra-terminal (BET) family of proteins, ABBV-744, with the aim of assessing its preclinical efficacy and exploring the pathways by which the compound regulates microglia-mediated neuroinflammation.
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Doctor pointing at liver

BIX 2024: From graveyard to breakthrough, MASH candidates on rise

July 11, 2024
By Marian (YoonJee) Chu
Nonalcoholic steatohepatitis was renamed, for the first time in 34 years, to metabolic dysfunction associated steatohepatitis (MASH), but a name change is far from being the biggest development in the field, according to experts at Bioplus Interphex (BIX) Korea 2024.
Read More
Hands holding holographic intestine
Gastrointestinal

Novel AI-designed anti-IBD compound divulged

July 11, 2024
The use of artificial intelligence (AI) in drug discovery has shown promise in recent years with a growing number of new compounds moving forward in the pipeline.
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Inflammatory

UCB patents new IL-6 release inhibitors

July 9, 2024
UCB SA has disclosed new interleukin-6 (IL-6) release inhibitors reported to be useful for the treatment of autoimmune and inflammatory disorders.
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Test tubes, dropper and capsules
Genitourinary/sexual function

Targeting KAT14 as a new therapeutic strategy against endometriosis-associated fibrosis

July 9, 2024
Researchers from Southern Medical University and affiliated organizations assessed the molecular mechanisms behind TGF-β-induced fibrosis in ovarian endometrioma.
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Illustration of a helper t cell in the bloodstream
Immune

Finely slicing T cells yields rare, disease-associated subtypes

July 9, 2024
By Mar de Miguel
A new methodology based on the regulation of genetic enhancers has made it possible to develop a cellular map that reveals new types of helper T cells related to immunological disorders that could be explored for the development of new therapies. “I am very interested in the function of rare T cells, and I am trying to analyze their function by eliminating certain rare T cells with antibodies with ADCC [antibody-dependent cell-mediated cytotoxicity] activity or by disrupting genes that characterize rare T cells in animal models,” senior author Yasuhiro Murakawa told BioWorld.
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Inflammatory

UCB describes new IL-17 modulators

July 8, 2024
UCB SA has identified imidazotriazine derivatives acting as interleukin-17 (IL-17) modulators reported to be useful for the treatment of inflammation and autoimmune diseases.
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Inflammatory

Immvention Therapeutix patents new inflammasome inhibitors

July 8, 2024
Immvention Therapeutix Inc. has disclosed benzimidazole-containing compounds acting as inflammasome inhibitors reported to be useful for the treatment of inflammatory disorders.
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Drug vials

FDA grants approvals to Stelara, Neupogen, Eylea biosimilars

July 2, 2024
By Marian (YoonJee) Chu
The U.S. FDA approved three biosimilar products from Samsung Bioepis Co. Ltd., Tanvex Biopharma Inc. and Formycon AG as follow-on biologics to Stelara (ustekinumab), Neupogen (filgrastim) and Eylea (aflibercept), respectively, on June 28.
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