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BioWorld - Monday, January 30, 2023
Home » Topics » Respiratory, BioWorld

Respiratory, BioWorld
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Pliant posts positive phase IIa data in IPF

Jan. 23, 2023
By Lee Landenberger
No Comments
A lack of available options for treating idiopathic pulmonary fibrosis (IPF) is driving plenty of development into the indication. The latest data come from Pliant Therapeutics Inc., which posted positive 12-week interim data from 21 participants in the 320-mg dose group’s active arm and eight in the placebo arm in its phase IIa study of PLN-74809 (bexotegrast).
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Cross-section of a mouse lung infected with P. aeruginosa and treated with engineered M. pneumoniae
Newco news

Pulmobiotics is developing cell therapy for lung diseases, but with a twist

Jan. 19, 2023
By Anette Breindl
No Comments
Pulmobiotics Ltd., which was founded in 2019, is developing cell therapy for lung diseases, including lung cancer. But unlike other cell therapies for cancer, this one is based not on harnessing T cells but on engineering bacteria. The team has engineered Mycoplasma pneumoniae to deliver various therapeutic proteins to the lung, depending on the therapeutic indication.
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3D renderings of RSV
Respiratory

Targeting prefusion state is better bet for RSV vaccines

Jan. 5, 2023
By Mar de Miguel
No Comments
After comparing the response to the two types of vaccines for the respiratory syncytial virus (RSV) based on its fusion protein (F), prefusion (pre-F) versus postfusion (post-F) vaccines, scientists at the National Institutes of Health (NIH) and Astrazeneca plc have demonstrated that targeting the pre-F protein led to better protection. No more bets on RSV immunization based on the post-F protein of the virus. Laboratories can now bet all on red for the pre-F technology.
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The two phase IIIs of Verona: more positive data prompts NDA talk

Dec. 20, 2022
By Lee Landenberger
No Comments
After posting positive top-line data in August from its phase III ENHANCE-2 study of ensifentrine for treating chronic obstructive pulmonary disease (COPD), Verona Pharma plc now has positive results from the companion phase III study. The ENHANCE-1 trial of ensifentrine as a COPD maintenance treatment hit its primary and key secondary endpoints, prompting the company to say it plans to submit an NDA for the treatment to the U.S. FDA sometime in the first half of 2023.
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Right on the nose: Rigimmune’s acquisition of Subintro helps close the stem-loop

Oct. 27, 2022
By Lee Landenberger
No Comments
With its acquisition of Subintro Ltd., Rigimmune Inc. put a building block in place to further its development of stem-loop RNA therapeutics that selectively activate the innate immune sensor RIG-I. Subintro specializes in development and delivery of antiviral therapeutics for respiratory diseases caused by RNA viruses, including influenza, rhinovirus and SARS-CoV-2. Subintro’s technology allows the company to consider topical and nasal delivery.
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Antibodies attacking virus cell

Abbvie pays $255M up front for former ‘garage startup’ DJS Antibodies

Oct. 20, 2022
By Richard Staines
No Comments
U.K.-based seed investor Lifearc Ventures is celebrating a second major deal from its portfolio of companies after Abbvie Inc. bought the tiny former “garage startup" DJS Antibodies Ltd. for $255 million up front plus undisclosed milestone payments. DJS’ lead program is DJS-002, a potential first-in-class lysophosphatidic acid receptor 1 antagonist in preclinical studies for the treatment of idiopathic pulmonary fibrosis and other fibrotic diseases.
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Lungs and bronchi

Eloxx CF trial misses efficacy endpoint, shifting focus to Alport trial

Sep. 15, 2022
By Michael Fitzhugh
No Comments
After a midstage trial showed no benefit from adding ELX-02 (exaluren) to Kalydeco (ivacaftor, Vertex Pharmaceuticals Inc.) for certain cystic fibrosis (CF) patients, Eloxx Pharmaceuticals Inc. said it will discuss next steps for the program, its lead candidate, with the trial's sponsor, the CF Foundation. A proof-of-concept trial for EXL-02 in the rare kidney disease Alport syndrome will start later this year, the company said.
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Natural killer cell

Japan’s Healios advances its iPSC-derived gene engineered killer cells toward the clinic

Aug. 26, 2022
By Tamra Sami
No Comments
Japan’s Healios K.K. is in discussions with Japan’s Pharmaceutical and Medical Devices Agenc about the regulatory path forward for its Multistem somatic stem cell products, for which it conducted phase II/III trials in ischemic stroke and a phase II trial in acute respiratory distress syndrome.
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Lee’s Pharm acquires lucinactant from Windtree in $78.9M deal

Aug. 26, 2022
By Doris Yu
No Comments
Lee’s Pharmaceutical (HK) Ltd. and its affiliate, Zhaoke Pharmaceutical (Hefei) Co. Ltd., expanded their rights to lucinactant Surfaxin, lyophilized lucinactant Surfaxin LS and Aerosurf from Windtree Therapeutics Inc. in a $78.9 million global license deal to develop and commercialize the candidates for the treatment of preterm infants with respiratory distress syndrome and other potential indications.
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Breathing easier: Verona’s phase III in COPD hits primary and secondary endpoints

Aug. 9, 2022
By Lee Landenberger
No Comments
Top-line data from Verona Pharma plc’s phase III ENHANCE-2 study show its inhaled ensifentrine hit the primary and secondary endpoints in treating chronic obstructive pulmonary disease (COPD). Next up: data from the companion phase III, ENHANCE-1, which is expected by the end of 2022.
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