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Home » Topics » Drugs » Cell therapy

Cell therapy
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BioWorld Insider podcast: Gene and cell therapies will propel innovation

Oct. 7, 2024
By Lee Landenberger
Gene and cell therapies will drive innovation for the next 10 years, Claus Zieler, the chief commercial officer at Astellas Pharma Inc., said in the newest episode of the BioWorld Insider podcast. Developers are on the cusp of breakthroughs because a gene can now be replaced “and that means we can potentially cure a disease rather than intervening in a disease.”
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Enara’s ‘dark antigen’ work draws more pharma backing in series B

Oct. 4, 2024
By Nuala Moran
Dark genome miner Enara Bio Ltd. has closed a $32.5 million series B that will see the lead program targeting the first of a novel class of cancer antigens it has discovered through to the clinic. Enara calls these cancer antigens “dark antigens” (the name is trademarked). It says they can be found in solid tumors irrespective of the immune phenotype, and are often expressed at high prevalence across multiple different tumors.
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Enara’s ‘dark antigen’ work draws more pharma backing in series B

Oct. 3, 2024
By Nuala Moran
Dark genome miner Enara Bio Ltd. has closed a $32.5 million series B that will see the lead program targeting the first of a novel class of cancer antigens it has discovered through to the clinic. Enara calls these cancer antigens “dark antigens” (the name is trademarked). It says they can be found in solid tumors irrespective of the immune phenotype, and are often expressed at high prevalence across multiple different tumors.
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Purple macrophage

Resolution’s £64M series B to advance macrophage cell therapy

Oct. 3, 2024
By Nuala Moran
Resolution Therapeutics Ltd. is preparing for a phase I/II trial of its autologous engineered macrophage cell therapy, RTX-001, in the treatment of end-stage liver disease and has raised £63.5 million (US$83.3 million) to complete the study and to add further fibrotic and inflammatory disease programs to its portfolio. Recruitment to the study, to be conducted at 15 sites in Spain and the U.K., is due to start before the end of 2024, with the monocyte-derived patient macrophages being processed and modified at a facility in Edinburgh.
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Cells, DNA illustration
Endocrine/metabolic

Papillon’s PPL-002 awarded US orphan drug designation for Danon disease

Oct. 2, 2024
The FDA has awarded orphan drug designation to Papillon Therapeutics Inc.’s PPL-002, an experimental gene-modified CD34+ hematopoietic stem and progenitor cell (HSPC) therapy, for the treatment of Danon disease.
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Gold dollar sign inside gold cog
Cancer

Prime’s $3.61B Bristol Myers deal is year’s fourth largest

Oct. 1, 2024
By Lee Landenberger
In the year’s fourth-largest deal, Prime Medicine Inc. will collaborate with Bristol Myers Squibb Co. in a research collaboration and license agreement totaling $3.61 billion. The two companies plan to develop reagents for ex vivo T-cell therapies. While the programs and targets have yet to be disclosed, BMS is expanding its CAR T development, begun more than five years ago, with this deal.
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Illustration of women's reproductive organs
Immuno-oncology

Cartherics raises funding to advance TAG-72 CAR NK into clinic

Oct. 1, 2024
Cartherics Pty Ltd. has raised over its target of AU$15 million (US$10.3 million) in an oversubscribed private financing round. Funding will support a clinical trial for CTH-401, the company’s lead cell therapy for ovarian cancer, and expand its pipeline to include other diseases.
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Gold dollar sign inside gold cog

Prime’s $3.61B Bristol Myers deal is year’s fourth largest

Sep. 30, 2024
By Lee Landenberger
In the year’s fourth-largest deal, Prime Medicine Inc. will collaborate with Bristol Myers Squibb Co. in a research collaboration and license agreement totaling $3.61 billion. The two companies plan to develop reagents for ex vivo T-cell therapies. While the programs and targets have yet to be disclosed, BMS is expanding its CAR T development, begun more than five years ago, with this deal.
Read More
Nervous system illustration
Neurology/psychiatric

KYV-101 demonstrates CAR-mediated, CD19-dependent activity across neurological indications in vitro

Sep. 30, 2024
Researchers from Kyverna Therapeutics Inc. presented preclinical data for KYV-101, a first-in-class, fully human autologous anti-CD19 chimeric antigen receptor (CAR) T-cell therapy being developed for the treatment of patients with B-cell-driven neurologic autoimmune diseases, including multiple sclerosis and myasthenia gravis.
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Cell research illustration
Neurology/psychiatric

PPL-001 gets US orphan drug designation for Friedreich’s ataxia

Sep. 18, 2024
Papillon Therapeutics Inc.’s PPL-001 has been awarded orphan drug designation by the FDA for Friedreich’s ataxia. PPL-001 is an experimental gene-corrected CD34+ hematopoietic stem and progenitor cell (HSPC) therapy.
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