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Home » Topics » Drugs » Small molecule

Small molecule
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Avata, Oceanus partner on cannabidiol for epilepsy, schizophrenia

June 18, 2025
By Tamra Sami
No Comments
Avata Biosciences Holdings Ltd. and Oceanus Bio Inc. have inked a drug discovery and development deal worth up to $95 million for two of Avata’s cannabidiol compounds.
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Cheering Immuneering, Street hopes high in pancreatic

June 18, 2025
By Randy Osborne
No Comments
Immuneering Corp.’s phase IIa data from an ongoing trial in pancreatic cancer disclosed June 17 impressed Wall Street and brought renewed attention to the perennially difficult indication, at which drug developers continue to fling themselves with varied mechanisms.
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Deal illustration

Astrazeneca makes $5.3B drug R&D pact with CSPC

June 17, 2025
By Marian (YoonJee) Chu
No Comments
CSPC Pharmaceutical Group Ltd. announced June 13 that it struck a potential $5.33 billion deal with Astrazeneca plc to develop novel preclinical small-molecule candidates using CSPC’s AI-driven drug development platform.
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BIO 2025: Bridging the gap with a ‘molecule-to-medicine expressway’

June 17, 2025
By Karen Carey
No Comments
For years, the biopharma industry has spent increasing amounts of money on R&D without improving success rates, leaving many executives searching for new, more predictable drug development paths.
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Deal illustration

Astrazeneca makes $5.3B drug R&D pact with CSPC

June 16, 2025
By Marian (YoonJee) Chu
No Comments
CSPC Pharmaceutical Group Ltd. announced June 13 that it struck a potential $5.33 billion deal with Astrazeneca plc to develop novel preclinical small-molecule candidates using CSPC’s AI-driven drug development platform.
Read More

For $795M, Sage is added to Supernus’ CNS quiver

June 16, 2025
By Lee Landenberger
No Comments
Supernus Pharmaceuticals Inc. is buying Sage Therapeutics Inc. for about $795 million. The deal brings Supernus, already firmly in the CNS market, the only U.S. FDA-approved oral treatment for postpartum depression. Supernus CEO Jack Khattar said he believes sales will support the acquisition, but some analysts had their doubts.
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Win for ROS1 as Nuvation’s Ibtrozi cleared for NSCLC

June 12, 2025
By Randy Osborne
No Comments
Slightly ahead of the assigned June 23 PDUFA date, Nuvation Bio Inc. scored the U.S. FDA’s go-ahead for Ibtrozi (taletrectinib) to treat adults with locally advanced or metastatic ROS1-positive non-small-cell lung cancer (NSCLC).
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ABPI: UK’s rebate rates ‘send a terrible message’ to global investors

June 11, 2025
By Nuala Moran
No Comments
The U.K. government has doubled the rate that pharmaceutical companies must repay on sales of branded drugs, under the statutory rebate scheme, to a record 31.3%. Only 1-2% of total sales of branded drugs fall under the statutory scheme, but the increase is seen as a sign that an ongoing review of the voluntary scheme is not going well.
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Philochem, BMS ink $1.35B deal for prostate cancer candidate OncoACp3

June 11, 2025
By Jennifer Boggs
No Comments
Philochem AG’s ligand-targeting approach drew to the table Bristol Myers Squibb Co. in a potential $1.35 billion agreement granting BMS subsidiary Rayzebio Inc. exclusive worldwide rights to OncoACP3, a diagnostic and therapeutic candidate targeting prostate cancer.
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AI-generated illustration of heart and metabolic impact

Deep Apple signs big Novo deal for cardiometabolic small molecules

June 11, 2025
By Lee Landenberger
No Comments
Deep Apple Therapeutics Inc. could bring in as much as $812 million in a new collaboration and license deal with Novo Nordisk A/S. The total includes an unspecified up-front payment, research costs and milestones. The two plan to develop and commercialize oral small molecules for non-incretin G-protein coupled receptor targets for treating cardiometabolic diseases, including obesity, a core specialty for Novo Nordisk.
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