RTI International has divulged vancomycin derivatives with siderophore modification reported to be useful for the treatment of gram-negative and gram-positive bacterial infections.

Nutshell Biotech (Shanghai) Co. Ltd. has identified nitrogen-containing macrocyclic compounds acting as DNA polymerase θ (POLθ) inhibitors reported to be useful for the treatment of cancer.

Scientists at CeMM-Forschungsinstitut für Molekulare Medizin GmbH and Max Planck Society for the Advancement of Science EV have synthesized proteolysis targeting chimera (PROTAC) compounds comprising a DDB1- and CUL4-associated factor 11 (DCAF11) binding moiety covalently linked to a different protein targeting moiety through a linker.

Deliver Therapeutics Inc. has disclosed protein kinase inhibitors reported to be useful for leukemia.

Thirtyfivebio Ltd. has described G protein-coupled receptor GPR35 antagonists reported to be useful for the treatment of cancer, fibrosis, inflammatory, cardiovascular, gastrointestinal and immunological disorders.

Humanwell Healthcare (Group) Co. Ltd. has identified kinesin-like protein KIF18A inhibitors reported to be useful for the treatment of atopic dermatitis, autoimmune disease, cancer, Crohn’s disease, psoriasis and ulcerative colitis.

Astrazeneca AB has divulged proteolysis targeting chimeras (PROTACs) comprising an E3 ubiquitin ligase cereblon unit coupled to an androgen receptor (AR) targeting moiety via a linker acting as AR degradation inducers reported to be useful for the treatment of cancer.

Researchers at Baylor College of Medicine and Deliver Therapeutics Inc. have synthesized protein kinase inhibitors reported to be useful for the treatment of cancer and psoriasis.

Scientists at University of California and University of Illinois have disclosed compounds acting as estrogen receptor β (ER-β; ESR2) ligands.

Ferring BV has described FSH receptor agonists reported to be useful for the treatment of infertility.