Beijing Neox Biotech Co. Ltd. has patented proteolysis targeting chimera (PROTACs) compounds comprising an E3 ubiquitin ligase binding moiety covalently linked to wee1-like protein kinase (Wee1) binding moiety through a linker reported to be useful for the treatment of cancer.
Chia Tai Tianqing Pharmaceutical Group Co. Ltd. has identified proteolysis targeting chimera (PROTAC) compounds comprising a E3 ubiquitin ligase-binding moiety coupled to RACα serine/threonine-protein kinase AKT targeting moiety through a linker reported to be useful for the treatment of prostate cancer.
Allianthera Boston Inc. and Allianthera (Suzhou) Biopharmaceutical Co. Ltd. have described cyclin-dependent kinase 12 (CDK12) inhibitors reported to be useful for the treatment of cancer.
Thirtyfivebio Ltd. has divulged G-protein coupled receptor GPR35 antagonists reported to be useful for the treatment of cancer, inflammation, fibrosis, cardiovascular, gastrointestinal and immunological disorders.
TYK Medicines Inc. has patented compounds reported to be useful for the treatment of Alzheimer’s, Parkinson’s and Huntington diseases as well as amyotrophic lateral sclerosis, epilepsy and spinocerebellar ataxia.
Immunodesigners Co. Ltd. has discovered optical isomers of 2'-fluoro-6'-methylene carbocyclic adenosine monophosphate prodrug reported to be useful for the treatment of chronic hepatitis B.
Beijing Qinghui Liannuo Biotechnology Co. Ltd. has described compounds acting as butyrophilin subfamily 3 member A1 (BTN3A1) and 2A1 ligands reported to be useful for the treatment of cancer, autoimmune, inflammatory, cardiovascular disorders and infections.
Ajax Therapeutics Inc. has divulged tyrosine-protein kinase JAK2 inhibitors reported to be useful for the treatment of hematologic cancer (particularly, leukemia and lymphoma), myelofibrosis, polycythemia vera and essential thrombocythemia.
Insmed Inc. has identified cathepsin C (dipeptidyl peptidase I; DPP-1) inhibitors reported to be useful for the treatment of cancer, inflammatory bowel disease, bronchiectasis, asthma, cystic fibrosis, lupus nephritis, pulmonary hypertension and rheumatoid arthritis.
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