Alceptor Therapeutics Inc. has divulged α2B-adrenoceptor agonists reported to be useful for the treatment of pain and hypertension.

Evotec International GmbH has synthesized integrin α4β7 (LPAM-1) antagonists reported to be useful for the treatment of ulcerative colitis and Crohn’s disease.

Kalvista Pharmaceuticals Ltd. has identified coagulation factor XII (FXIIa) inhibitors reported to be useful for the treatment of hereditary angioedema, atherosclerosis, inflammatory disorders, neurodegeneration, diabetic retinopathy, SARS-CoV-2 infection (COVID-19), stroke and thrombotic disorders, among others.

A group of researchers have disclosed spike glycoprotein (SARS-CoV-2; COVID-19 virus)/ACE2 interaction inhibitors in a new patent.

Vanderbilt University has described muscarinic M4 receptor positive allosteric modulators (PAMs) reported to be useful for the treatment of Alzheimer’s disease, pain, schizophrenia, sleep disorders and cognitive disorders.

Gandeeva Therapeutics Inc. has divulged serine/threonine-protein kinase B-raf (BRAF)/MAP2K1 (MEK1) interaction stabilizers reported to be useful for the treatment of brain metastasis.

MD Biopharm Co. Ltd. has identified compounds acting as mitogen-activated protein kinase kinase kinase 11 (MAP3K11; MLK3) and kinase 1 (MAP4K1; HPK1; MEKKK1) inhibitors reported to be useful for the treatment of cancer, viral infection, Parkinson’s disease, nonalcoholic or metabolic dysfunction-associated steatohepatitis (NASH/MASH) and tuberculosis.

Chia Tai Tianqing Pharmaceutical Group Co. Ltd. has synthesized compounds acting as tyrosine-protein kinase receptor UFO (AXL) inhibitors reported to be useful for the treatment of cancer.

Shanghai Qilu Pharmaceutical Research and Development Centre Ltd. has disclosed proteolysis targeting chimera (PROTAC) compounds.

Shenzhen Salubris Pharmaceuticals Co. Ltd. has described tertiary amine compounds reported to be useful for the treatment of stroke, atherosclerosis, thrombosis, coronary heart disease and aortic valve stenosis.