Chengdu Kangnuoxing Biopharma Inc. and Keymed Biosciences Co. Ltd. have identified antibody-drug conjugates comprising antibodies targeting carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5; CEA; CD66e) covalently linked to a cytotoxic drug through a linker reported to be useful for the treatment of cancer.
Meta Pharmaceutical (HK) Ltd. and Shenzhen Moyuan Pharmaceuticals Co. Ltd. have synthesized lactate dehydrogenase A (LDHA) inhibitors reported to be useful for the treatment of primary hyperoxaluria.
Hangzhou Zhongmei Huadong Pharmaceutical Co. Ltd. has disclosed antibody-drug conjugates consisting of antibodies covalently linked to a cytotoxic drug through a linker reported to be useful for the treatment of cancer.
Immuse Therapeutics Inc. has described heterocyclic compounds acting as leucine-rich repeat kinase 2 (LRRK2; dardarin) inhibitors reported to be useful for the treatment of cancer.
Nikang Therapeutics Inc. has divulged proteolysis targeting chimera (PROTAC) compounds comprising an E3 ubiquitin ligase binding moiety covalently linked to a cyclin-dependent kinase 2 (CDK2)- and/or CDK4-targeting moiety through a linker reported to be useful for the treatment of cancer.
Prelude Therapeutics Inc. has synthesized tyrosine-protein kinase JAK2 inhibitors reported to be useful for the treatment of cancer, myelofibrosis, essential thrombocythemia and graft-vs.-host disease.
Centauri Therapeutics Ltd. has disclosed conjugates consisting of a peptide such as polymyxin or its derivative covalently linked to a rhamnose unit via a linker reported to be useful for the treatment of infections.
Merck Sharp & Dohme LLC has described proteolysis targeting chimera (PROTAC) compounds comprising an E3 ubiquitin ligase binding moiety covalently linked to a GTPase KRAS G12D mutant-targeting moiety via a linker reported to be useful for the treatment of cancer.
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