Researchers from Harvard Medical School, Yale University and University of Leiden have uncovered two new potential biomarkers of dysregulated glucose metabolism in Alzheimer’s disease (AD). Glucose hypometabolism is consistently observed in AD but the molecular changes behind this are unclear. Findings from recent research have indicated dysregulation of glycolysis markers in AD cerebrospinal fluid (CSF) and tissue.

Plasmalogens are a type of phospholipid that play significant roles in membrane fluidity and cellular processes such as vesicular fusion and signal transduction. Previous studies with natural plasmalogens have shown their role in neuroinflammation and memory function improvement.

There is a strong link between the loss of TAR DNA-binding protein 43 (TDP-43) function and the development of frontotemporal dementia (FTD)...

Several neurodegenerative disorders have TAR DNA-binding protein 43 (TDP-43) inclusions as a pathological hallmark; thus, the development of PET tracers able to detect TDP-43 aggregates is essential to advance the diagnosis and treatment monitoring in diseases such as frontotemporal dementia, amyotrophic lateral sclerosis and others.

Researchers from Prothena Biosciences Ltd. recently presented preclinical data for the full effector-function IgG1 monoclonal antibody PRX-012, which binds with high affinity to both soluble and insoluble forms of toxic amyloid-β (Aβ) aggregates.

Sigma nonopioid intracellular receptor 1 (SIGMAR1) is a protein enriched in motor neurons (MNs), and mutations in its gene have been previously linked to various motor neuron diseases (MNDs). Researchers from Welab Barcelona and affiliated organizations recently presented preclinical data for two novel SIGMAR ligands, EST-79232 and EST-79376, being evaluated as potential candidates for the prevention of MN degeneration.

Researchers from Assembly Biosciences Inc. reported on the preclinical characterization of ABI-5366, a potent helicase-primase inhibitor against both HSV-1 and HSV-2.

Researchers from Nihon University and Aomori University have discovered a novel δ...

Lung cancer is the second most frequently diagnosed cancer worldwide where the non...