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Endocrine/Metabolic

Tetra Pharm pursues CB1 antagonist to suppress appetite for weight loss

Feb. 8, 2024
Tetra Pharm Technologies ApS has announced it is advancing its cannabinoid CB1 receptor antagonist, TPT-0701, into preclinical testing for appetite suppression.
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Tape measure wrapped around scale
Endocrine/Metabolic

Scholar Rock’s SRK-439 shows promising results in mice with obesity

Feb. 8, 2024
Agonists of the glucagon-like peptide-1 receptor (GLP-1RAs) have emerged as effective treatments for obesity, but have a negative impact on lean mass during weight loss.
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Digital lungs illustration
Respiratory

Anima Biotech’s IPF candidate disrupts transformation of fibroblasts into fully differentiated myofibroblasts

Feb. 8, 2024
Anima Biotech Inc. has released promising preclinical data on its new candidate, which has potential for treating idiopathic pulmonary fibrosis (IPF).
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Neurology/Psychiatric

Targeting PFKFB3 provides neuroprotection in stroke models

Feb. 8, 2024
Stroke is the main neurologic cause of global morbidity and mortality with a global prevalence of more than 100 million last year. Under neuropathological conditions such as excitotoxicity associated with stroke, the pro-glycolytic enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3) enhances glucose consumption which leads to redox stress and apoptotic neuronal death.
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Non-Hodgkin lymphoma cells in the blood flow
Cancer

Enzyme degrader could avoid drug resistance in B-cell cancers

Feb. 8, 2024
By Mar de Miguel
Bruton tyrosine kinase (BTK) enzyme inhibitors used to treat B-cell cancers, including chronic lymphocytic leukemia (CLL) and non-Hodgkin lymphoma, also produce resistance by causing mutations in the protein. Now, a study on the BTK degrader NX-2127 showed the compound could be effective in eliminating BTK regardless of its mutations.
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Other news to note for Feb. 8, 2024

Feb. 8, 2024
Additional early-stage research and drug discovery news in brief, from: Bergenbio, Maia Biotechnology, Virpax Pharmaceuticals.
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Cancer

Humanwell divulges new dual microtubule destablizers/Src inhibitors

Feb. 7, 2024
Humanwell Healthcare (Group) Co. Ltd. has described heterocyclic fused benzene ring compounds acting as dual microtubule destabilizers (tubulin polymerization inhibitors) and proto-oncogene tyrosine-protein kinase Src (SRC; SRC1) inhibitors.
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Cancer

Oncopia Therapeutics and University of Michigan report CRBN ligands

Feb. 7, 2024
Oncopia Therapeutics Inc. (dba Proteovant Therapeutics Inc.) and the University of Michigan have prepared and tested new protein cereblon (CRBN) ligands expected to be useful for the treatment of cancer and inflammatory disorders.
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Musculoskeletal

TREM2 agonists revealed in Muna Therapeutics patent

Feb. 7, 2024
Muna Therapeutics ApS has disclosed new triggering receptor expressed on myeloid cells 2 (TREM2) agonists reported to be useful for the treatment of osteoporosis, rheumatoid arthritis, systemic lupus erythematosus, type 2 diabetes, obesity, metabolic dysfunction-associated steatotic liver disease, neurodegenerative and inflammatory bowel disease, among others.
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Infection

Janssen Pharmaceutica patent discloses new compounds for SARS-CoV-2 infection

Feb. 7, 2024
Janssen Pharmaceutica NV researchers have identified new compounds for the treatment of SARS-CoV-2 infection (COVID-19).
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