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Disintegrating coronavirus
Infection

SARS-CoV-2 peptides cause severe illness when virus breaks

Feb. 2, 2024
By Mar de Miguel
COVID-19 severity remains open to several questions. Researchers at the University of California Los Angeles (UCLA) have revealed how SARS-CoV-2 causes acute inflammation instead of the symptoms of a common cold. This effect could be initiated by the peptide fragments of the coronavirus released when the host eliminates the virus, which can form pro-inflammatory complexes that trigger an amplified immune response.
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Heart and lungs
Cardiovascular

MCJ protein at the heart of new options to manage pulmonary hypertension

Feb. 1, 2024
By Coia Dulsat
Researchers at the Spanish National Center for Cardiovascular Research (CNIC) have identified a new target that may open new avenues into pulmonary hypertension (PH) treatment. Their findings were published in Science Advances on Jan. 19, 2024.
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Macrophage releasing cytokines as a part of the body's immune response.
Biomarkers

BMP-9 is a prognostic marker in sepsis

Feb. 1, 2024
Bone morphogenetic protein 9 (BMP-9), also known as growth/differentiation factor 2, is a member of the transforming growth factor-β family of cytokines, which exerts its biological effects through binding to a complex formed by ALK1 and BMPR2.
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Other news to note for Feb. 1, 2024

Feb. 1, 2024
Additional early-stage research and drug discovery news in brief, from: Chemomab Therapeutics.
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Cancer

Chengdu Easton Biopharmaceuticals describes new CDK7 inhibitors for cancer

Feb. 1, 2024
Chengdu Easton Biopharmaceuticals Co. Ltd. has identified cyclin-dependent kinase 7 (CDK7) inhibitors reported to be useful for the treatment of cancer.
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Immune

Cgenetech divulges new JAK2 inhibitors

Feb. 1, 2024
Cgenetech (Suzhou, China) Co. Ltd. has synthesized tyrosine-protein kinase JAK2 inhibitors reported to be useful for the treatment of autoimmune diseases, myeloproliferative diseases and graft-versus-host disease.
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Substance Use & Poisoning

Pharward Biotechnology patents new E3 ubiquitin-protein ligase SIAH1 modulators to treat cocaine dependence

Feb. 1, 2024
Pharward Biotechnology Inc. Pte Ltd. has disclosed compounds acting as E3 ubiquitin-protein ligase SIAH1 modulators reported to be useful for the treatment of cocaine dependence.
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Brain clay model
Neurology/Psychiatric

FDA clears IND for Jaguar’s JAG-201 for genetic form of ASD and Phelan-McDermid syndrome

Feb. 1, 2024
Jaguar Gene Therapy LLC’s IND application for JAG-201, a gene therapy for a genetic form of autism spectrum disorder (ASD) and Phelan-McDermid syndrome (PMS; 22q13.3 deletion syndrome), has been cleared by the FDA.
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Immuno-oncology

Combining AMP vaccination with TCR T-cell therapies leads to improved and durable antitumor efficacy

Feb. 1, 2024
Amphiphile (AMP)-modification of peptide antigens and molecular adjuvants has been previously demonstrated to enhance lymphatic delivery and retention, resulting in potent expansion of cognate endogenous T-cell responses.
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Release of malaria parasites from red blood cell
Infection

PRL-2 plays crucial role in progression to severe malaria and acute lung injury

Feb. 1, 2024
Neutrophils are the immune system’s most abundant effector cells, which play a defensive role of host cells and clear pathogens by phagocytosis, degranulation and neutrophil extracellular trap (NET) release.
Read More
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