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Ear, Nose & Throat

Sensorion's SENS-501 can enter clinic for genetic hearing loss

Jan. 19, 2024
Sensorion SA has received approval in Europe for its clinical trial application (CTA) to initiate a...
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Components of a radiopharmaceutical
Cancer

Ratio raises series B to advance radiotherapeutic into clinic

Jan. 19, 2024
Ratio Therapeutics Inc. has closed a $50 million series B financing to expand application of its proprietary technology platforms, Trillium and Macropa, to develop novel best-in-class radiopharmaceuticals.
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Blister beetle on a flower
Cancer

Blistering agent derivative exerts anticancer activity

Jan. 19, 2024
Cantharidin, a natural product coming from blister beetles, has anti-proliferative activity in several cancer cell lines such as leukemia, myeloma or colon cancer cells.
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Biomarkers

LINC00853 may promote gastric cancer progression, study shows

Jan. 19, 2024
There is increasing interest in studying exosome molecules, and particularly long non-coding RNAs (lncRNAs), in the diagnosis of gastric cancer. Microarray analysis was performed from samples obtained from patients with gastric cancer who underwent endoscopic resection.
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Illustration of COVID-19 virus cells affecting brain
Infection

Proteomic signature can identify long COVID

Jan. 19, 2024
By Anette Breindl
Researchers at ETH Zurich have identified a proteomic signature that could recognize long COVID six months after acute infection. Biologically, the signature indicated that the complement system remained active in patients with long COVID six months after infection. Translationally, it could lead to a diagnostic test for long COVID, and suggests that targeting the complement system could be a therapeutic approach to prevent or treat the disorder.
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Neurology/Psychiatric

Mainline Biosciences discovers new tachykinin NK1 receptor antagonists

Jan. 18, 2024
Mainline Biosciences (Shanghai) Co. Ltd. has described peptides acting as tachykinin NK1 receptor antagonists reported to be useful for the treatment of pain and opioid dependence.
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Immuno-oncology

Chulalongkorn University presents new PD-1/PD-L1 modulators

Jan. 18, 2024
Chulalongkorn University has divulged programmed cell death 1 (PDCD1; PD-1; CD279)/PD-1 ligand 1 (PD-L1; CD274) modulators reported to be useful for the treatment of cancer.
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Cancer

Cincinnati Children’s Hospital Medical Center describes new inhibitors of IRAK and FLT3

Jan. 18, 2024
Cincinnati Children’s Hospital Medical Center has identified IL-1 receptor-associated kinase (IRAK) and/or FLT3 (FLK2/STK1) inhibitors reported to be useful for the treatment of cancer, autoimmune disease and inflammatory disorders.
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Cancer

Shanghai Institute of Materia Medica divulges new CRBN/target protein interaction inducers

Jan. 18, 2024
Shanghai Institute of Materia Medica of the Chinese Academy of Sciences has synthesized molecular glue compounds targeting protein cereblon (CRBN) acting as CRBN/target protein interaction inducers reported to be useful for the treatment of cancer.
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Cancer

US and UK researchers patent new DYRK1A inhibitors

Jan. 18, 2024
Researchers at University of Arizona and University of Dundee have disclosed dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A (DYRK1A) inhibitors reported to be useful for the treatment of cancer, diabetes, osteoarthritis, Down syndrome, inflammatory disorder, autoimmune and Alzheimer’s disease.
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