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BioWorld - Wednesday, April 8, 2026
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Endocrine/metabolic

FFA1 and FFA4 receptor agonists disclosed in Dartmouth College patent

Oct. 29, 2024
Dartmouth College has divulged fatty acid mimetics acting as free fatty acid FFA1 receptor (GPR40) and/or FFA4 receptor (GPR120) agonists reported to be useful for the treatment of obesity and type 2 diabetes.
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Infection

French scientists describe new conjugates for bacterial infections

Oct. 29, 2024
Scientists at Centre Hospitalier Regional Universitaire de Lille, Centre National de la Recherche Scientifique, Institut National De La Santé et de la Recherche Médicale, Institut Pasteur de Lille and Université de Lille have patented conjugates comprising siderophore moieties covalently linked to cargo moieties through a linker reported to be useful for the diagnosis and treatment of bacterial infections.
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Neurology/psychiatric

Biocells Biotech discovers new AQP4 inhibitors for cerebral ischemia

Oct. 29, 2024
Biocells (Beijing) Biotech Co. Ltd. has identified aquaporin-4 (AQP4) inhibitors reported to be useful for the treatment of cerebral ischemia.
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Cancer

National Institutes of Pharmaceutical R&D divulges new FGFR2 inhibitors

Oct. 29, 2024
National Institutes of Pharmaceutical R&D Co. Ltd. has synthesized fibroblast growth factor receptor 2 (FGFR2) inhibitors reported to be useful for the treatment of cancer.
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Cancer

Baobab Aibio patents new YAP1/TEAD interaction inhibitors

Oct. 29, 2024
Baobab Aibio Co. Ltd. has disclosed transcriptional coactivator YAP1/transcriptional enhancer factor (TEAD) interaction inhibitors reported to be useful for the treatment of cancer.
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Cancer

Selective POLθ inhibitor enhances response to PARP inhibition in HR-deficient tumor models

Oct. 29, 2024
Moma Therapeutics Inc. has reported preclinical results on MOMA-313, a potent and selective DNA polymerase θ (POLθ) inhibitor under development for the treatment of homologous recombinant (HR)-deficient cancers.
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Drug R&D concept image.
Cancer

Insilico Medicine divulges novel HPK1 inhibitor with robust antitumor activity

Oct. 29, 2024
Hematopoietic progenitor kinase 1 (HPK1) is expressed in hematopoietic cells, including T cells, B cells and dendritic cells (DCs). Suppression of HPK1 activity has shown an antitumor effect in preclinical models.
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Lung cancer driven by the Kras oncogene shown in purple
Cancer

RMC-8839 unveils dependencies underlying KRAS-mutant cancers

Oct. 29, 2024
The development of covalent KRAS G12C inhibitors has represented a significant advance for non-small-cell lung cancer treatment, but other mutations such as KRAS G13C/D still lack effective treatments.
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Illustration of ovaries and uterus with endometriosis
Genitourinary/sexual function

Lisata announces preclinical research agreement to study certepetide with bevacizumab for endometriosis

Oct. 29, 2024
Lisata Therapeutics Inc. has entered into a sponsored research agreement with the University of Cincinnati to investigate Lisata’s novel cyclic peptide product candidate, certepetide, in combination with bevacizumab in a preclinical animal model for the treatment of endometriosis.
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Gloved hand holding vial, syringe
Infection

Novel Shigella conjugate vaccine protects mice against virulent S. flexneri 6 challenge

Oct. 29, 2024
Previous reports have disclosed the development of Shigella conjugate vaccines (SCVs) using a platform squaric acid chemistry conjugation approach and carrier protein recombinant fragment of tetanus toxin heavy chain (rTTHc).
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