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Infection

Janssen patent discloses new compounds for mycobacterial infections

Nov. 21, 2024
Janssen Pharmaceutica NV has identified new compounds reported to be useful for the treatment of mycobacterial infections.
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Cancer

Sanofi patents new MAPK7 inhibitors for cancer

Nov. 21, 2024
Sanofi SA has synthesized pyridoimidazolone compounds acting as mitogen-activated protein kinase 7 (MAPK7; ERK5) inhibitors potentially useful for the treatment of cancer.
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Human heart within crosshairs
Cardiovascular

ETX-258 improves cardiac function and structural remodeling post-MI

Nov. 21, 2024
At the American Heart Association’s Scientific Sessions, E-Therapeutics plc presented preclinical data for ETX-258, a Galomic siRNA being developed for the treatment of heart failure.
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DNA mutations or genetic disorder concept art
Biomarkers

HOXB13 gene involved in metastatic omentum carcinoma, study shows

Nov. 21, 2024
Primary tumors arising in the gastrointestinal system, ovary or pancreas may spread and lead to secondary cancers such as metastatic omentum cancer.
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Art concept for hematologic cancer
Cancer

EG-011 exerts robust antiproliferative activity in hematological cancer models

Nov. 21, 2024
The Wiskott-Aldrich syndrome protein (WASp) is expressed exclusively in hematopoietic cells and presents either an autoinhibited or activated conformation. EG-011 is a first-in-class activator of the autoinhibited form of WASp designed for the treatment of hematological cancers.
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Cardiovascular

Linoleic acid metabolite reduces atrial arrhythmia by normalizing CaMKII levels

Nov. 21, 2024
Researchers from Ohio State University hypothesized that 12,13-diHOME may act by inhibiting the proarrhythmic molecule Ca2+/calmodulin-dependent kinase II (CaMKII).
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Joint pain
Musculoskeletal

Gilead’s GS-6791 ameliorates arthritis symptoms in mice

Nov. 21, 2024
Interleukin-1 receptor-associated kinase 4 is critical in the modulation of inflammatory responses through Toll-like receptor and IL-1R signaling.
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Gastrointestinal

New preclinical data on CVI-2742 for treating MASH

Nov. 21, 2024
The efficacy and capabilities of CVI Pharmaceuticals Inc.'s CVI-2742, a THR-β agonist, were tested in nonhuman primates.
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Hand holding lightbulb
Drug design, drug delivery & technologies

Aizen Therapeutics emerges from stealth to develop full D-amino acid therapeutics

Nov. 21, 2024
Aizen Therapeutics has emerged from stealth with a focus on early-stage programs powered by its novel drug discovery platform, Dax.
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Illustration of tau proteins in Alzheimer's disease
Neurology/psychiatric

Voyager Therapeutics to advance tau silencing gene therapy for Alzheimer’s disease

Nov. 21, 2024
Voyager Therapeutics Inc. has selected a lead development candidate, VY-1706, for its tau silencing gene therapy program in Alzheimer’s disease. The company anticipates filing an IND application with the FDA and a clinical trial application (CTA) with Health Canada for VY-1706 in 2026.
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