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Cancer

TACC3 inhibition enhances antitumor efficacy of T-DM1 in HER2-positive breast cancer

Feb. 20, 2024
In a recent study, scientists from Medical University of South Carolina aimed to evaluate whether immunogenic cell death (ICD) can trigger resistance to anticancer therapies and explore potential therapeutic opportunities to revive ICD and restore drug sensitivity.
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Artistic rendering of the KRAS protein.
Drug Design, Drug Delivery & Technologies

Zapata AI announces use of quantum-enhanced generative AI to generate novel KRAS inhibitors

Feb. 20, 2024
Zapata Computing Inc. (Zapata AI) scientists have demonstrated the first instance of a generative model running on quantum hardware outperforming state-of-the-art classical models in generating viable cancer drug candidates.
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Illustration of tau accumulating in a neuron cell.
Neurology/Psychiatric

Voyager Therapeutics reports updates from preclinical programs targeting tau for Alzheimer’s disease

Feb. 20, 2024
Voyager Therapeutics Inc. has announced new data from two preclinical programs targeting pathological tau for the treatment of Alzheimer’s disease.
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Cardiovascular

C3 inhibitor CP40-KK protects rats from PAH development

Feb. 20, 2024
Pulmonary arterial hypertension (PAH) is a severe condition characterized by vasoconstriction and remodeling of the small pulmonary arteries, driven by a complement-dependent activation of macrophages, for which an effective treatment is lacking. Chinese researchers have investigated the potential of a complement C3 inhibitor polypeptide, CP40-KK, as an approach for treating PAH. To do this, they used a model in which PAH was induced in rats by monocrotaline.
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AI generated illustration of a brain on fire
Immune

Finding the good in autoantibodies could REAP broad benefits

Feb. 20, 2024
By Anette Breindl
Autoantibodies call to mind disease – autoimmune disease, to be exact. But the physiological roles of autoantibodies are, at the very least, more complex than this view accounts for. “The autoantibody reactome is extraordinary,” Aaron Ring told BioWorld. “Nearly everyone has autoantibodies, whether they know it or not.”
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Cancer

Anadolu University and Atatürk University identify carbonic anhydrase inhibitors

Feb. 19, 2024
Anadolu University and Atatürk University have jointly described novel 3,5-disubstituted-1,2,4-oxadiazole derived compounds acting as carbonic anhydrase type I and/or type II inhibitors.
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Ear, Nose and Throat

New 15-PGDH inhibitors detailed in Scinnohub Pharmaceutical patent

Feb. 19, 2024
Work at Scinnohub Pharmaceutical Co. Ltd. has led to the identification of new 15-hydroxyprostaglandin dehydrogenase (15-PGDH) inhibitors.
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Inflammatory

UCB reports new IL-17 modulators

Feb. 19, 2024
Imidazotriazine derivatives acting as interleukin-17 (IL-17) modulators have been described in a UCB SA patent and are reported to be potentially useful for the treatment of inflammatory disorders and autoimmune diseases.
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Cancer

Sanofi discloses MAPK7 inhibitors for cancer

Feb. 19, 2024
A Sanofi SA patent describes imidazopyridine compounds acting as mitogen-activated protein kinase 7 (MAPK7; ERK5) inhibitors and reported to be useful for the treatment of cancer.
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Hematologic

Ildong Pharmaceutical patents ANO6 blockers for treatment of thrombosis

Feb. 19, 2024
Ildong Pharmaceutical Co. Ltd. have synthesized heteroaryl derivative compounds acting as anoctamin-6 (ANO6; TMEM16F) blockers.
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