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BioWorld - Thursday, April 23, 2026
Breaking News: Best of BioWorld Science: Q1Breaking News: Best of BioWorld: Q1Breaking News: Best of BioWorld: Q1
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Endocrine/metabolic

Islet-targeted gene therapy RJVA-001 leads to durable weight loss in obese mice

Nov. 14, 2024
Researchers from Fractyl Health Inc. presented preclinical data for RJVA-001, a novel pancreatic gene therapy.
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Dermatologic

Enveda advances ENV-294 into clinic for atopic dermatitis

Nov. 14, 2024
Enveda Therapeutics Inc. has received U.S. IND clearance and advanced into phase I trials with ENV-294, its naturally derived anti-inflammatory.
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3D rendering conceptualizing theranostics
Cancer

Artbio and 3B Pharmaceuticals to advance α-radioligand therapy for solid tumors

Nov. 14, 2024
Artbio Inc. and 3B Pharmaceuticals GmbH have signed a worldwide, exclusive license and research agreement to develop an advanced preclinical stage first-in-class peptide α-radioligand therapy for the treatment of solid tumors.
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Adenovirus cells
Neurology/psychiatric

Preclinical data on SPK-10001 AAV-based gene therapy released

Nov. 14, 2024
Spark Therapeutics Inc. has presented preclinical data on SPK-10001, an engineered adeno-associated virus (AAV).
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Heart and DNA
Cardiovascular

Avidity Biosciences unveils new cardiology development candidates

Nov. 14, 2024
Avidity Biosciences Inc. has announced two new precision cardiology development candidates targeting rare genetic cardiomyopathies. AOC-1086 targets phospholamban (PLN) cardiomyopathy and AOC-1072 targets protein kinase AMP-activated noncatalytic subunit γ2 (PRKAG2) syndrome.
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X/Y chromosomes
Healing the health divide

The science of gender-based medicine: many reasons, many manifestations

Nov. 14, 2024
By Anette Breindl
At the BioFuture 2024 conference held in New York in November, Seema Kumar, the CEO of Cure, described women’s health as something that has been directed at the “bikini area.” That “bikini” bias extended to both diseases and their causes – women’s health covered the breasts and reproductive system, and its causes were hormonal. Both concepts are far too narrow.
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Group of multigenerational, multiracial women

Healing a health divide (that’s long overdue)

Nov. 14, 2024
By Lynn Yoffee
It’s difficult to fathom that the health of half the world’s population is underserved. But it’s a hard truth. There are many conditions that disproportionately impact women. Other conditions and diseases affect women in different ways than men. Decades of research excluding women from clinical trials and investment decisions in male-dominated board rooms have ignored these facts. Though an increasing number of women are now managing investments and driving the research, it’s all still woefully behind. In BioWorld’s new report, Healing the health divide, we’ve highlighted the disparities.
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John Mendlein, executive chairman and interim CEO, Vesalius
Neurology/psychiatric

Vesalius-GSK $650M pact: Targeting Parkinson’s root causes

Nov. 13, 2024
By Karen Carey
More than two years since emerging from stealth, Vesalius Therapeutics Inc. signed its first major pharma deal with GSK plc. Worth up to $650 million and possibly more if an option is exercised, the multitarget alliance aims to discover and develop novel treatments for Parkinson’s disease and another neurodegenerative indication.
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Businesspeople shaking hands, meeting with cityscape, charts
Cancer

Flare and Schrödinger join multibillion-dollar collaborations

Nov. 13, 2024
By Lee Landenberger
Flare Therapeutics Inc. will receive $70 million in cash up front from Roche Holding AG, and the deal could ultimately bring the company about $1.8 billion plus royalties. Flare will search for small molecules that can be used to treat undruggable transcription factors to treat cancer. Also, Novartis AG will pay computational-chemistry expert Schrödinger Inc. $150 million up front and as much as $2.3 billion in milestones to develop several candidates along with up to $892 million in R&D and milestone payments.
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Cardiovascular

Shenzhen Salubris Pharmaceuticals discovers new tertiary amine compounds

Nov. 13, 2024
Shenzhen Salubris Pharmaceuticals Co. Ltd. has described tertiary amine compounds reported to be useful for the treatment of stroke, atherosclerosis, thrombosis, coronary heart disease and aortic valve stenosis.
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