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BioWorld - Monday, July 7, 2025
Breaking News: Trump administration impacts continue to roil the life sciences sectorBreaking News: Trump administration impacts continue to roil the life sciences sectorBreaking News: House passes H.R. 1, restoring R&D tax cutsBreaking News: Self-amplifying mRNA technology underscored for next big pandemic
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Cancer

Shanghai Haihe Biopharma divulges new SOS1 inhibitors for cancer

Jan. 19, 2024
Shanghai Haihe Biopharma Co. Ltd. has synthesized compounds acting as son of...
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Cancer

Dana-Farber Cancer Institute patents new EGFR mutant inhibitors with particular use for NSCLC

Jan. 19, 2024
Dana-Farber Cancer Institute Inc. has disclosed fused bicyclic EGFR (HER1; erbB10) mutant...
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Antibodies
Infection

FP-directed antibodies protect against mucosal SHIV challenge

Jan. 19, 2024
Researchers from National Institute of Allergy and Infectious Diseases and affiliated organizations presented data from a study that aimed to assess the protective efficacy of the human fusion peptide (FP) broadly neutralizing antibody (bNAb), VRC34.01, along with two FP vaccine-elicited rhesus macaque mAbs, DFPH-a.15 and DF1W-a.01, to protect naïve rhesus macaques against mucosal challenge with SHIV(BG505).
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Endocrine/Metabolic

Korro presents data for KRRO-110 for α-1 antitrypsin deficiency

Jan. 19, 2024
Korro Bio Inc. has highlighted new data for KRRO-110, its first development candidate for the potential treatment of α-1 antitrypsin deficiency (AATD), an inherited genetic disorder caused by single nucleotide variants in the SERPINA1 gene.
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Klebsiella pneumonia
Immune

CARB-X grant supports Syntiron's maternal vaccine to prevent sepsis in newborns

Jan. 19, 2024
Combating Antibiotic-Resistant Bacteria Biopharmaceutical Accelerator (CARB-X) is awarding Syntiron US$1.7 million to develop a maternal vaccine that targets Escherichia coli and Klebsiella pneumoniae, two bacterial species that cause a large portion of neonatal sepsis infections.
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Neurology/Psychiatric

Endocannabinoid reuptake inhibitor SYT-510 granted EU IND

Jan. 19, 2024
Synendos Therapeutics AG has received approval from the European Medicines Agency (EMA) to initiate a first-in-human trial of its lead asset, SYT-510, a first-in-class inhibitor that modulates a newly identified drug target in the endocannabinoid system (ECS) to restore healthy brain physiology.
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Mesothelioma
Cancer

SWTX-143 shows activity in Hippo-mutant mesothelioma

Jan. 19, 2024
Researchers from Springworks Therapeutics Inc. and affiliated organizations presented the discovery and preclinical characterization of a novel covalent and irreversible YAP/TAZ-TEAD inhibitor, SWTX-143, being developed for the treatment of mesothelioma.
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Neurology/Psychiatric

Rogdi(-/-) mouse recapitulates symptoms of Kohlschütter-Tönz syndrome

Jan. 19, 2024
Researchers from Université de Strasbourg and affiliated organizations presented new mouse...
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G protein-coupled receptors: rhodopsin and the T-cell, dopamine and GABA B receptors
Cardiovascular

New G protein-coupled receptor kinase 5 inhibitor disclosed

Jan. 19, 2024
G protein-coupled receptor kinase 5 (GRK5) promotes cardiac hypertrophy; it is involved in...
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Ear, Nose & Throat

Sensorion's SENS-501 can enter clinic for genetic hearing loss

Jan. 19, 2024
Sensorion SA has received approval in Europe for its clinical trial application (CTA) to initiate a...
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