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BioWorld - Tuesday, June 17, 2025
Breaking News: Trump administration impacts continue to roil the life sciences sectorBreaking News: Trump administration impacts continue to roil the life sciences sectorBreaking News: Trump administration impacts continue to roil the life sciences sectorBreaking News: Trump administration impacts continue to roil the life sciences sector
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Holiday notice

Jan. 2, 2024
In accordance with the publishing schedule, BioWorld Science was not published on Monday, Jan. 1, 2024.
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Cancer

Kinoteck Therapeutics reports new RSK-2 inhibitors

Dec. 29, 2023
Kinoteck Therapeutics Co. Ltd. have prepared and tested new ribosomal protein S6 kinase alpha-3 (RSK-2; MAPKAPK-1b) inhibitors potentially useful for the treatment of cancer.
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Endocrine/Metabolic

Biocells Biotech describes AQP4 inhibitors

Dec. 29, 2023
Biocells (Beijing) Biotech Co. Ltd. has patented isoquinolinone derivatives acting aquaporin-4 (AQP4) inhibitors and thus reported to be useful for the treatment of hypervolemia (fluid overload) and cerebral ischemia.
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Immune

Zhuhai Yufan Biotechnologies discloses new GSPT1 degraders

Dec. 29, 2023
Work at Zhuhai Yufan Biotechnologies Co. Ltd. has led to the development of proteolysis targeting chimeras (PROTACs) comprising an E3 ubiquitin ligase binding moiety coupled to eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)-targeting moiety.
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Infection

RSV inhibitors revealed in Janssen patent

Dec. 29, 2023
Janssen R&D (Ireland) has identified compounds acting as viral fusion inhibitors and reported to be useful for the treatment of respiratory syncytial virus (RSV) infections.
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Cancer

US Department of Health and Human Services patents new LATS inhibitors

Dec. 29, 2023
A U.S. patent describes new serine/threonine-protein kinase LATS1, LATS2 and/or RAC serine/threonine-protein kinase inhibitors.
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Cancer cells
Cancer

METTL3 inhibitor shows efficacy and synergy with venetoclax in preclinical models of AML

Dec. 29, 2023
Researchers from Epics Therapeutics SA presented preclinical data for EP-102, a novel small-molecule inhibitor of N6-adenosine-methyltransferase catalytic subunit (METTL3), being developed for the treatment of cancer.
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CAR T cell with implanted gene strand
Immuno-oncology

Next-generation CAR EBV T-cell therapy from Atara Biotherapeutics

Dec. 29, 2023
Chimeric antigen receptor (CAR) therapies targeted against CD19 have been widely used for the treatment of B-cell malignancies. However, the down-regulation of CD19 can lead to relapse, and autologous CAR T therapies have limitations that need to be addressed.
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Microscopic image of acute myeloid leukemia (AML) cells.
Cancer

HC-7366 inhibits venetoclax resistance mechanisms in models of AML

Dec. 29, 2023
Researchers from Hibercell Inc. recently presented preclinical data for HC-7366, a first-in-class direct activator of GCN2 (general control nonderepressible 2) currently in phase I development for the treatment of solid tumors (NCT05121948).
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Endocrine/Metabolic

Neurobo Pharmaceuticals submits IND in US for DA-1726

Dec. 29, 2023
Neurobo Pharmaceuticals Inc. has submitted an IND application to the U.S. FDA for DA-1726.
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