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Cancer

Tempest Therapeutics presents new TREX1 inhibitors for cancer

Jan. 17, 2024
Tempest Therapeutics Inc. has divulged three-prime repair exonuclease 1 (TREX1) inhibitors reported to be useful for the treatment of cancer.
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Cancer

Chinese researchers describe new GTPase KRAS mutant inhibitors for cancer

Jan. 17, 2024
Researchers at Guangzhou Salustier Biosciences Co. Ltd. and Jinan University (Guangdong) have identified selenium-containing heterocyclic compounds acting as GTPase KRAS (G12D mutant) inhibitors reported to be useful for the treatment of cancer.
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Cancer

Biogen divulges new TYK2 inhibitors

Jan. 17, 2024
Biogen Inc. has synthesized non-receptor tyrosine-protein kinase TYK2 inhibitors reported to be useful for the treatment of cancer, autoimmune disease, cardiovascular disorders, fibrosis, inflammatory disorders, liver diseases, pain and neurodegeneration, among others.
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Cancer

Biofront patents new inhibitors of HPK1, FLT3 and AURKA for cancer

Jan. 17, 2024
Biofront Ltd. disclosed HPK1, FLT3 and AURKA inhibitors reported to be useful for the treatment of cancer.
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Cancer cell targeted in crosshairs
Immuno-oncology

ROR1-targeting PBA-0405 cleared to enter phase 0 trial for solid tumors

Jan. 17, 2024
Presage Biosciences Inc. has announced that the FDA has issued a study may proceed notification for testing a pre-GMP drug candidate with the company’s Comparative In Vivo Oncology (CIVO) platform. Owned by Pure Biologics, the drug candidate, PBA-0405, is a ROR1-targeting compound that has been engineered to induce tumor cell killing by cytotoxic immune cells.
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Neurology/Psychiatric

Solid Biosciences’ SGT-003 granted orphan drug designation for Duchenne muscular dystrophy

Jan. 17, 2024
Solid Biosciences Inc.’s SGT-003 has been granted orphan drug designation by the FDA. The company’s next-generation Duchenne muscular dystrophy gene therapy candidate was also granted fast track designation last month.
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Ischemic stroke
Neurology/Psychiatric

Aruna’s AB-126 cleared to enter clinic for acute ischemic stroke

Jan. 17, 2024
Aruna Bio Inc. has gained FDA clearance for its IND application for AB-126, enabling initiation of a phase Ib/IIa trial in acute ischemic stroke.
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Microscope with beakers and flasks
Endocrine/Metabolic

E-Therapeutics outlines pipeline progress

Jan. 17, 2024
E-Therapeutics plc has offered a pipeline update, following the nomination of novel target genes, which have yielded promising results in preclinical studies.
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Musculoskeletal

PPP1R15A identified as therapeutic target for osteoclast differentiation

Jan. 17, 2024
The stress-responsive protein PPP1R15A (protein phosphatase 1, regulatory subunit 15 A) promotes the unfolded protein response and restores protein homeostasis.
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Ocular

Nanogenics prepares to advance development of ECP-105 for post-surgical treatment of glaucoma

Jan. 17, 2024
N4 Pharma plc’s subsidiary Nanogenics Ltd. has signed a contract to start the formulation and sequence selection work to prepare its ECP-105 product for testing in preclinical studies.
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