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BioWorld - Monday, July 6, 2026
Home » Authors » Brian Orelli

Articles by Brian Orelli

Fighting peanut allergies before the attacks start

March 13, 2017
By Brian Orelli
For children and adults with peanut allergies, the only therapeutic option comes from post-exposure treatment with epinephrine, such as Epipen (Mylan NV) or Auvi-q (Kaleo Inc.), to dampen the anaphylactic reaction. Even then, 100 to 150 people die from food allergies each year.
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Life sciences companies popular targets for lawsuits

Feb. 27, 2017
By Brian Orelli
Life sciences companies are increasingly becoming targets of securities fraud lawsuits. After being flat from 2014 to 2015 at 39 cases filed in each year, the number of class action fraud lawsuits against life sciences companies increased more than 70 percent in 2016 to 67 cases, according to a new report from law firm Dechert LLP.
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Mixed bag for drug prices; specialty drugs see big jump

Feb. 13, 2017
By Brian Orelli
In its annual Drug Trend Report, pharmacy benefit manager Express Scripts Holding Co. reported that the net price Express Scripts' clients paid for drugs increased 2.5 percent in 2016 compared to the year prior, 27 percent smaller increase than in 2015.
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Looking for novel targets to fight fibrotic diseases

Jan. 30, 2017
By Brian Orelli
Earlier this month, Evotec AG and MaRS Innovation announced the launch of Fibrocor Therapeutics LP. The startup joins the growing number of companies working on drugs to fight fibrosis.
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After decades, cardiovascular gene therapy makes final push

Jan. 23, 2017
By Brian Orelli
It's been a long road for Generx (Ad5FGF-4), a gene therapy designed to express fibroblast growth factor-4 (FGF-4) to increase vascularization in the heart.
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CEOs, analysts and bankers looking for a prosperous 2017

Jan. 9, 2017
By Brian Orelli
"Thank goodness 2016 is over," the Cowen and Co. biotechnology analyst team wrote in its monthly biotech thermometer report to clients.
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VC investments and IPOs down, but here’s a halftime pep talk

Jan. 4, 2017
By Brian Orelli

Venture capital investors gave it the old college try, but apparently they spent more time watching bowl games than investing in U.S. private biopharmaceutical companies in the fourth quarter.


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Following the channel to new non-opioid pain drugs

Dec. 12, 2016
By Brian Orelli
Given the side effects and potential addiction issues with opioid drugs, pain-drug specialist Purdue Pharma L.P. is exploring options for other mechanisms of actions. Last week the company announced a deal with Anabios Corp. to accelerate Purdue's Nav1.7 sodium ion channel preclinical drug candidates.
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Synthetic biology charges on with different strategies

Dec. 5, 2016
By Brian Orelli
The idea of synthetic biology – using computers, rather than trial and error, to rationally design drugs – has been around for years. But Woburn, Mass.-based Abpro is taking it to the next level with rationally designed antibodies using its Diversimmune platform. Labor intensive steps that used to take two to three years can now be done using bioinformatics that reduce the design time down to less than two months.
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Avoiding empirical diagnosis of antibiotic resistance

Nov. 28, 2016
By Brian Orelli
"Treat first, ask questions later" is typically the procedure for treating bacterial infections because the answers to those questions take a couple of days to elucidate while the lab cultures the bacteria to determine the strain.
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