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BioWorld - Monday, December 29, 2025
Home » Authors » Brian Orelli

Articles by Brian Orelli

If you can't beat 'em, join 'em; looking for immuno-onc boost

Dec. 12, 2015
By Brian Orelli

Last week, Threshold Pharmaceuticals Inc. announced the failure of two phase III evofosfamide trials, one in pancreatic cancer and another in soft tissue sarcoma, but Barry Selick, CEO of the South San Francisco-based company, gave investors some hope that the drug might work in combination with immune checkpoint inhibitors. (See BioWorld Today, Dec. 8, 2015.)


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FDA advisory committees on the decline, results vary

Dec. 7, 2015
By Brian Orelli
It's been three years since the FDA Safety and Innovation Act, the most recent reauthorization of the user fee program, was enacted, providing plenty of data on advisory committee meetings to examine.
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Accelerating clinical trials by looking in the rearview mirror

Nov. 23, 2015
By Brian Orelli
Transcelerate Biopharma Inc., a nonprofit established by 10 of the industry's largest pharmas in 2012 – and has doubled its membership since then – is charged with the task of reducing redundancy and speeding drug development for its member drug companies. (See BioWorld Today, Sept. 26, 2012.)
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California continues to lead the way in life sciences

Nov. 16, 2015
By Brian Orelli
San Francisco and San Diego may have a friendly rivalry for the top area of California for biotechs, but when you add them together, the combination is a force to be reckoned with.
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Most me-too drugs start before risk is abated

Nov. 9, 2015
By Brian Orelli
There can be only one first-in-class drug. Every drug developed after that is a me-too drug in the most basic sense.
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AACR-NCI-EORTC abstracts: Triple the cancer targeting

Nov. 2, 2015
By Brian Orelli
The American Association for Cancer Research (AACR), the National Cancer Institute (NCI) and the European Organisation for Research and Treatment of Cancer (EORTC), are teaming up to put on the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics scheduled to kick off on Thursday.
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Antibody-drug conjugates press on treating cancer

Oct. 26, 2015
By Brian Orelli
Antibody-drug conjugates (ADCs) may have fallen behind immunotherapy in the oncology-hype department, but plenty of companies are pressing forward with their ADC drugs. Last week, there was an entire conference – the 2015 World ADC Summit – held in San Diego dedicated to the discovery, development and manufacturing of ADCs.
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Covalent Data streamlines product discovery, JDRF joins

Oct. 16, 2015
By Brian Orelli

Covalent Data Inc. is looking to become a one-stop shop for drug companies, investment banks and venture capitalists to discover products available for license and company formation while helping academics get across the valley of death.


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36-year-old beta blocker gets new life as a lung drug

Oct. 13, 2015
By Brian Orelli
Smokers have plenty of options to quit, but many restart because of chronic "smoker's cough" caused by mucus buildup in the lungs that forms after they stop smoking.
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36-year-old beta blocker gets new life as a lung drug

Oct. 12, 2015
By Brian Orelli
Smokers have plenty of options to quit, but many restart because of chronic "smoker's cough" caused by mucus buildup in the lungs that forms after they stop smoking.
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