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BioWorld - Monday, December 22, 2025
Home » Authors » Brian Orelli

Articles by Brian Orelli

Molecules and RNA enclosed by a lipid bilayer
Newco news

Addition launches with an all-RNA, lipid nanoparticle-based gene therapy

Dec. 17, 2025
By Brian Orelli
No Comments
Addition Therapeutics came out of stealth mode to highlight its Precise RNA-Mediated Insertion of Transgenes (PRINT) gene therapy platform. The system is based on research of retrotransposons by Kathleen Collins’ laboratory at University of California, Berkeley, that was spun out into Addition in 2021.
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Novo Nordisk semaglutide pill

CTAD 2025: Diagnosing semaglutide’s failure in Alzheimer’s trials

Dec. 4, 2025
By Brian Orelli
No Comments
A little over a week after announcing that the Evoke and Evoke+ studies failed to show that oral semaglutide could slow cognition decline in patients with Alzheimer’s disease, investors and researchers got the first look at the actual data from the studies, which were presented at the Clinical Trials on Alzheimer’s Disease 2025 meeting.
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Illustration of head with maze that is missing parts
Neurology/psychiatric

CTAD 2025: The challenges of combination therapies for dementia

Dec. 4, 2025
By Brian Orelli
No Comments
At the Clinical Trials on Alzheimer’s Disease 2025 meeting, a panel of experts discussed the need for developing combination therapies for the complex diseases that result in Alzheimer's disease and other dementias.
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Illustration of head with maze that is missing parts

CTAD 2025: The challenges of combination therapies for dementia

Dec. 3, 2025
By Brian Orelli
No Comments
At the Clinical Trials on Alzheimer’s Disease 2025 meeting, a panel of experts discussed the need for developing combination therapies for the complex diseases that result in Alzheimer's disease and other dementias.
Read More

Protego secures $130M in series B for its AL amyloidosis program

Dec. 1, 2025
By Brian Orelli
No Comments
Protego Biopharma Inc. closed an oversubscribed $130 million series B financing that will be used to advance PROT-001, the company’s treatment for amyloid light (AL) chain amyloidosis. a plasma cell disorder where the cells produce abnormal, misfolded immunoglobulin light chain proteins.
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CRISPR Cas9 illustration
Cancer

Azalea exits stealth to develop its in vivo gene engineering technology

Nov. 10, 2025
By Brian Orelli
No Comments
San Francisco Bay Area researchers from UC Berkeley, UC San Francisco and Stanford University have combined their technologies to create Azalea Therapeutics Inc., a company focused on editing cells in vivo.
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CRISPR Cas9 illustration
Newco news

Azalea exits stealth to develop its in vivo gene engineering technology

Nov. 6, 2025
By Brian Orelli
No Comments
San Francisco Bay Area researchers from UC Berkeley, UC San Francisco and Stanford University have combined their technologies to create Azalea Therapeutics Inc., a company focused on editing cells in vivo.
Read More
Bispecific antibodies with heavy chain in green and pink, light chain in blue and yellow
Cancer

Neok Bio launches with $75M to develop bispecific ADCs

Nov. 6, 2025
By Brian Orelli
No Comments
Neok Bio Inc. was formed earlier this year and is already on schedule to file an IND in a few months for its two bispecific antibody-drug conjugates (ADCs) to treat various types of tumors. The biotech got a leg up on development from its principal investor, Korean biotech ABL Bio Inc., where the discovery work was accomplished.
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Bispecific antibodies with heavy chain in green and pink, light chain in blue and yellow
Newco news

Neok Bio launches with $75M to develop bispecific ADCs

Nov. 5, 2025
By Brian Orelli
No Comments
Neok Bio Inc. was formed earlier this year and is already on schedule to file an IND in a few months for its two bispecific antibody-drug conjugates (ADCs) to treat various types of tumors.
Read More
Thymus illustration
Immune

Zag Bio launches with $80M to dampen immune response via thymus

Oct. 29, 2025
By Brian Orelli
No Comments
Zag Bio Inc. came out of stealth mode with $80 million in funding so far, including a recently closed series A financing, to develop its platform for autoimmune diseases using drugs targeted to the thymus where thymic regulatory cells are produced.
Read More
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