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BioWorld - Sunday, March 29, 2026
Home » Authors » Brian Orelli

Articles by Brian Orelli

Bispecific antibodies with heavy chain in green and pink, light chain in blue and yellow
Immune

Dualitas launches with $65M to advance bispecifics for I&I

Sep. 17, 2025
By Brian Orelli
No Comments
Dualitas Therapeutics Inc. exited stealth mode with a $65 million series A investment that was co-led by Versant Ventures and Qiming Venture Partners USA.
Read More
Hand holding money plant
Newco news

Allrock snags $50M for its in-licensed ROCK inhibitor

Sep. 16, 2025
By Brian Orelli
No Comments
Allrock Bio Inc. secured $50 million in a series A round co-led by Versant Ventures and Westlake Biopartners to advance ROC-101, an oral pan-rho-associated protein kinase (ROCK) inhibitor to treat pulmonary arterial hypertension and pulmonary hypertension with interstitial lung disease.
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Bispecific antibodies with heavy chain in green and pink, light chain in blue and yellow

Dualitas launches with $65M to advance bispecifics for I&I

Sep. 16, 2025
By Brian Orelli
No Comments
Dualitas Therapeutics Inc. exited stealth mode with a $65 million series A investment that was co-led by Versant Ventures and Qiming Venture Partners USA.
Read More
Cervical cancer cell

Antiva looks to cut cervical cancer off before it starts

Aug. 29, 2025
By Brian Orelli
No Comments
Antiva Biosciences Inc. has developed an intravaginal topical treatment, ABI-2280, for high-risk cervical infections with human papillomavirus (HPV). In a phase Ib/II study, after two weeks of treatment at the highest dose of the DNA polymerase inhibitor, 46% of patients were negative for high-risk HPV at week 12, compared to just 16% of patients treated with placebo.
Read More
Asa Abeliovich, founder and CEO, Leal
Newco news

Leal secures $30M to advance neuro-metabolic therapies

Aug. 28, 2025
By Brian Orelli
No Comments
Leal Therapeutics Inc. is taking advantage of new genetic data that suggest products from metabolic pathways are involved in psychiatric and neurodegenerative diseases.
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Seedling growing in cracked pavement

Purpose-driven longevity fund launches in face of regulatory issues

Aug. 19, 2025
By Brian Orelli
No Comments
Singapore-based Immortal Dragons has launched with $40 million under management, mostly from its founder Boyang Wang, with a focus on investing in early stage companies developing treatments to extend life.
Read More
Avalyn inhaler

Avalyn secures $100M for inhaled pulmonary fibrosis candidates

July 23, 2025
By Brian Orelli
No Comments
Following up on the $175 million it raised in September 2023, Avalyn Pharma Inc. secured an additional $100 million in an oversubscribed series D financing round to support development of its inhaled treatments for pulmonary fibrosis.
Read More
Avalyn inhaler

Avalyn secures $100M for inhaled pulmonary fibrosis candidates

July 22, 2025
By Brian Orelli
No Comments
Following up on the $175 million it raised in September 2023, Avalyn Pharma Inc. secured an additional $100 million in an oversubscribed series D financing round to support development of its inhaled treatments for pulmonary fibrosis.
Read More
Illustration of kidney with DNA structures
Newco news

Renasant launches with $54.5M to develop drugs for a genetic kidney disease

July 15, 2025
By Brian Orelli
No Comments
Launched out of 5AM Ventures’ 4:59 Initiative, Renasant Bio Inc. has secured $54.5 million in seed funding to support development of treatments for autosomal dominant polycystic kidney disease (ADPKD), a genetic disease caused by mutations in the PKD1 and PKD2 genes, which encode polycystin proteins PC1 and PC2 that come together to form a calcium ion channel vital for kidney function.
Read More

Apogee’s Apex phase II reads out for APG-777 in atopic dermatitis

July 7, 2025
By Brian Orelli
No Comments
Apogee Therapeutics Inc. plans to enter a crowded atopic dermatitis market with established drugs, such as Dupixent (dupilumab, Regeneron Pharmaceuticals Inc. and Sanofi SA) and Ebglyss (lebrikizumab-lbkz, Eli Lilly and Co.), which are sold by much larger competitors. But the company thinks it can compete with its anti-IL-13 antibody, APG-777, thanks to the drug’s 77 day half-life that may allow it to be dosed only two to four times a year in the maintenance phase, compared to 13 to 26 injections per year for the established competitors.
Read More
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