Brickell Biotech Inc., of Miami, landed a $7 million Series B financing with a new partner, Amorepacific Ventures, which is affiliated with Amorepacific Group, a large Korean aesthetics company.
The FDA's complete response letter (CRL) for its Heplisav hepatitis B vaccine was no surprise to Dynavax Technologies Corp., of Berkeley, Calif., as it had extensive behind-the-scenes conversations with the FDA between the November advisory committee meeting and the CRL issued over the weekend.
Tesaro Inc. topped up its cash with a $75 million public offering to support development and clinical trials of its oncology pipeline products. The company expects net proceeds of $69.7 million to support operations for the next 12 months.
Puma Biotechnology Inc. said its Phase III trial of PB272 (neratinib) will be conducted under a special protocol assessment from the FDA, providing specific guidance for design, endpoints and statistical analysis in the trial.
A partnership between Roche AG and Chiasma Inc., of New York, promises to take the pain out of therapy for acromegaly, the overproduction of growth hormone.
Eylea, a newly approved drug for wet age-related macular degeneration, racked up $276 million in sales in 4Q 2012 for Regeneron Pharmaceuticals Inc., and $838 million for the year overall, driving total revenues of $415 million in the 4Q and $1.4 billion for the year.
Stock in AVEO Pharmaceuticals Inc. softened following a clinical trial update released in conjunction with the company's full year 2012 earnings. Trial design may have confounded results for tivozanib, which show overall survival (OS) trends favoring the comparator drug Nexavar (sorafenib, Onyx Pharmaceuticals Inc. and Bayer AG), with OS of 28.8 months for tivozanib and 29.3 months for sorafenib (p = 0. 105).
StemCells Inc. reported positive results from the first patient cohort of a Phase I/II trial of its human neural stem cell product for spinal cord injury, and investors responded enthusiastically, driving the Newark, Calif.-based company's stock up 21 percent.
Lycera Corp. doubled its sweet 2011 deal with Merck and Co. Inc., of Whitehouse Station, N.J., in a new agreement designed to expand on the companies' prior relationship, which has centered on retinoic acid-related orphan receptor (ROR[gamma]t).
Shares of OxiGene Inc. bounced 14.8 percent Thursday on news that its Phase II study of Zybrestat and Avastin in ovarian cancer demonstrated acceptable tolerability in an interim toxicity analysis.
