Threshold Pharmaceuticals Inc. saw its shares fall 19.7 percent Monday, following release of an update to its Phase IIb trial of TH-302 in pancreatic cancer.
F2G Ltd., of Manchester, UK, will use a new $30 million equity financing round to jump a lead candidate from its F3 series of preclinical compounds into first-in-man studies.
Healthpoint Biotherapeutics, of Fort Worth, Texas, began a Phase III trial of its allogeneic living cell bioformulation, HP802-247, for venous leg ulcers. The study will assess wound closure with HP802-247 plus compression therapy over a period of 12 weeks.
Zalicus Inc., of Cambridge, Mass., is immediately terminating its development program for Synavive after a Phase IIb trial in rheumatoid arthritis failed to show meaningful clinical benefit compared to prednisolone, the active glucocorticoid component of the drug.
Debt financing of up to $15 million, plus a Series E preferred stock financing closed in the second quarter, will help KaloBios Pharmaceuticals Inc., of South San Francisco, advance its monoclonal antibody therapeutics through Phase II trials in asthma and cystic fibrosis, as well as fund a Phase I trial in cancer.
An ambitious new grant for up to $20 million from the California Institute of Regenerative Medicine (CIRM) will support StemCells Inc.'s preclinical development of its HuCNS-SC neural stem cell product in Alzheimer's disease over a four-year period. The goal of the grant will be filing an investigational new drug application within that time frame.
F2G Ltd., of Manchester, UK, will use a new $30 million equity financing round to jump a lead candidate from its F3 series of preclinical compounds into first-in-man studies.
When J. Michael Pearson, CEO of Valeant Pharmaceuticals International Inc., reached out to Medicis Pharmaceuticals International Inc. to discuss terms for a potential merger, it was the third time the two companies had had such discussions in the last 18 months. In previous talks, the value of Medicis' broad-spectrum tetracycline antibiotic, Solodyn (minocycline), had been a sticking point.
