An international study led by Nanyang Technological University in Singapore has designed and synthesized broad-spectrum antimicrobial polymers (AMPs) and demonstrated the safety and efficacy of two such agents against multidrug-resistant (MDR) bacteria in mouse models of sepsis.
An international study led by Nanyang Technological University in Singapore has designed and synthesized broad-spectrum antimicrobial polymers (AMPs) and demonstrated the safety and efficacy of two such agents against multidrug-resistant (MDR) bacteria in mouse models of sepsis.
A study by Australian microbiologists at Queensland, Melbourne and Griffiths universities has shown that the candidate neurodegenerative disease drug PBT-2, combined with a polymyxin antibiotic, induced potent antimicrobial activity against polymyxin-resistant gram-negative pathogens.
Chinese scientists have been the first to show that combining anti-cancer poly [ADP-ribose] polymerase (PARP) inhibitors with radiotherapy may be effective for treating ependymoma CNS tumors expressing elevated levels of the protein chromosome X open reading frame 67 (CXorf67).
A Chinese multi-omics analysis of the largest triple-negative breast cancer (TNBC) database compiled to date has identified three new distinct TNBC metabolic-pathway-based subtypes (MPSs), which could be targeted therapeutically.
Single-cell genomic analysis has shown that mutations in the KRAS oncogene co-opt a proto-oncogenic enhancer network in inflammation-induced metaplastic progenitor cells, initiating pancreatic ductal adenocarcinoma, Chinese researchers reported in the November 3, 2020, edition of Nature Cancer.
Japanese researchers have developed a new organoid biobank with which to identify molecular subtypes of rare gastroentero-pancreatic neuroendocrine neoplasms using genotype-phenotype mapping, they reported in the November 6, 2020, online edition of Cell.
Mutations in the annexin A11 gene contribute to motor neuron degeneration in amyotrophic lateral sclerosis by disrupting cellular calcium ion homeostasis and stress granule protein disassembly contributing to ALS neurodegeneration.
Australian geneticists have developed a new tool, the Single Nucleotide Association Test for CNVs, with which to analyze copy number variations and their associations in genetic neurodevelopmental disorders.
A collaborative Sino-Australian study led by scientists at the Institute of Ageing Research at Hangzhou Normal University in Chongqing has identified a new target for enhancing respiratory function and preventing stress-induced premature lung aging and fibrosis due to environmental stresses in mice.
