Lift Biosciences Ltd. has been awarded a grant of over £1 million (US$1.3 million) from Innovate UK that will fund a collaboration between Lift and researchers at the University of Cambridge.
Lift Biosciences Ltd. has reported a substantially marked increase in cancer killing with the attachment of HER2 chimeric antigen receptor (CAR) to its immunomodulatory alpha neutrophil (IMAN) cell therapy, using the company’s second-generation N-Lift (neutrophil only leukocyte infusion therapy) platform. Positive data support the potential of the In-Lift platform to produce a variety of genetically engineered CAR-IMANs to enhance killing and more targeted immunomodulation for different tumor targets.
Lift Biosciences Ltd. has announced successful proof-of-concept production of its patented cancer-killing alpha neutrophils from induced pluripotent stem cells (iPSCs). The proof of concept using In-Lift, the company’s second-generation platform which is derived from iPSCs, has shown that the alpha neutrophil type cells produced from iPSCs are able to be activated by chemokines released by tumors and that the cells actively destroy cancer cells.
Lift Biosciences Ltd. has released preclinical data demonstrating that its immunomodulatory alpha neutrophil product (IMANp) possesses both cytotoxic and immunomodulatory functionalities that could signal its potential to cure solid tumors. IMANp is generated from the hematopoietic stem cells of donors with exceptional anticancer innate immunity.
Lift Biosciences Ltd. and Minaris Regenerative Medicine GmbH have entered into a development and manufacturing partnership for N-Lift, Lift's first-in-class neutrophil progenitor-based leukocyte infusion therapy for the treatment of various cancer indications, including pancreatic cancer, lung cancer and other solid tumors.
Lift Biosciences Ltd. has shown that its first-in-class cell therapy destroyed on average over 90% of the tumoroid in a PDX (patient-derived xenograft) organoid across five solid tumor types, including bladder cancer, rectal cancer, colorectal cancer, gastric cancer and squamous cell non-small-cell lung cancer (NSCLC).
