Pemphigus vulgaris is an autoimmune skin disease mediated by autoantibodies to desmoglein-3 (DSG3). Since the adult murine model of this disease is quite limited, researchers aimed to develop a novel active adult pemphigus vulgaris murine model.
A mouse line with severe haploinsufficiency of about 92% reduction in coiled-coil and C2 domain-containing protein 1A (CC2D1A) expression was generated by breeding of Cc2d1a-knockout allele with C2d1a -/V5-HA mice to generate a compound heterozygous murine model of autism spectrum disorder (ASD).
