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Home » Newsletters » BioWorld

BioWorld

July 20, 2022

View Archived Issues
Ovarian cancer

VBL’s phase III of ofra-vec misses in ovarian cancer, dragging the stock with it

VBL Therapeutics Inc.’s phase III study of its gene therapy, ofranergene obadenovec, in treating ovarian cancer missed its primary endpoints, prompting the company to discontinue the trial and investors to pull way back. Shares of the Tel Aviv, Israel, and New York-based company’s stock (NASDAQ:VBLT) plunged 79% on July 20 to close at 43 cents per share. The $1.62 per share drop in value made it a penny stock. VBL shares hit their high on Nov. 8, closing at $2.53 each. Top-line data for ofra-vec, also known as VB-111, showed no statistically significant improvement in progression-free survival or overall survival. Read More
Emma Walmsley, CEO, GSK

New-look GSK faces moment of reckoning as consumer business spins off

GSK plc, formerly Glaxosmithkline plc, has begun a significant new chapter in its history with the spin-off this week of its consumer business known as Haleon plc. While the high-profile new listing of Weybridge, Surrey-based Haleon (LON:HLN), the largest in Europe in a decade, grabbed the headlines, investors are keeping a sharp eye on GSK now that it is free to focus on developing and marketing novel drugs. Read More
Senior author Kay Tye and co-first author Hao Li. Credit: Salk Institute

Neurotensin codes for positive valence in associative learning

In a sense, memories are useless without being linked to feelings. Without knowing whether a memory is good or bad, there is no way to seek out good experiences, and avoid bad ones. Now, investigators at the Salk Institute have identified neurotensin as a critical molecule for the assignment of such emotional valence. Read More

Kyowa Kirin stops development of KW-6356 for Parkinson’s disease

Japan’s Kyowa Kirin Co. Ltd. has stopped development of its adenosine A2a receptor antagonist, KW-6356, in Parkinson’s disease. Discovered internally by Kyowa Kirin, KW-6356  was studied in phase II trials in Japan for Parkinson’s disease, with results showing it was “potentially effective in relieving motor and non-motor symptoms both as a monotherapy and in combination with levodopa-containing therapy,” Kyowa said. However, development is now being discontinued after conducting an evaluation of the global regulatory landscape, development hurdles and potential timelines for market entry. Read More
Scientist injecting vaccine into Earth

Biopharma shares vision for pandemic preparedness, trial diversity

After political leaders across the globe made patents and other intellectual property safeguards the scapegoat for disparities in access to COVID-19 vaccines, the biopharma industry is sharing its vision for how to deal with the foundational issues of equitable access in pandemics to come – and it has nothing to do with IP waivers like the one World Trade Organization members adopted last month. Read More
Human aging illustration

Extending the human lifespan

In this multipart special report, BioWorld explores the concept of extending lifespan, which is surprisingly well-validated by basic research. The team examined the latest science, the key biological drivers that can be targeted pharmacologically and the companies developing these potential “Fountain of Youth” candidate drugs. Read More

The BioWorld Insider Podcast

In Extending the human lifespan, a BioWorld special report, the team examined the latest science, the key biological drivers that can be targeted pharmacologically and the companies developing potential “Fountain of Youth” candidate drugs. In this episode of the BioWorld Insider Podcast, the team discussed the report’s highlights and key takeaways.  

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Appointments and advancements for July 20, 2022

New hires and promotions in the biopharma industry, including: Bausch + Lomb, Enveric, GV20, Hotspot, Iomx, Nuvalent, Oligomerix, Prokidney, Resolution, Saliogen, Tectonic, Versantis, Vitro. Read More

Financings for July 20, 2022

Biopharmas raising money in public or private financings, including: 180, Auron, Bighat, Camp4. Read More

In the clinic for July 20, 2022

Clinical updates, including trial initiations, enrollment status and data readouts and publications: Allena, Artelo, Capricor, Cardurion, Genetx, Impel, Innovent, Oncurious, Scynexis, Sequana.

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Other news to note for July 20, 2022

Biopharma happenings, including deals and partnerships, grants, preclinical data and other news in brief: Antengene, Astrazeneca, Bavarian Nordic, BMS, Brii, Celularity, Creative, Inovio, Novavax, Oryzon, TSB, Turning Point. Read More

Regulatory actions for July 20, 2022

Regulatory snapshots, including global drug submissions and approvals, clinical trial approvals and other regulatory decisions and designations: Acadia, Apellis, Astrazeneca, Avadel, Daiichi, Destiny, Gilead, Incyte, Moderna, Viking. Read More

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