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BioWorld Science

July 5, 1996

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Lilly's 5-HT1F agonists for migraine

FDA issues nonapprovable letter for Avita; development elsewhere on track

ProCyte launches Iamin gel in U.S.

BMS describes antifungal effects of ascosteroside

Amphocil safe, effective in BMT patients

MedImmune seeks Canadian approval for RespiGam

MedImmune in-licenses HPV vaccine patents

Post-herpetic neuralgia data reviewed

HIV protease inhibitors reported by Pharmacia & Upjohn

Glaxo Wellcome, Vertex license anti-HIV patents from Searle

CPMP approves saquinavir for marketing

Synovir clinical program expanded

Phase III trials of Alferon N Injection initiated in HIV-positive patients

CryptoGam demonstrates clear antimicrobial effect in clinical trial

Vistide approved in U.S.

Various research groups announce independent discovery of receptor for HIV infection

AmBisome clinical efficacy in visceral leishmaniasis reported

Eisai claims prostaglandin/leukotriene production inhibitors for pain and inflammation

Searle claims NOS inhibitors

Mobic introduced in Argentina

Prosorba trial initiated in arthritis sufferers

Lidak reports discovery of antiinflammatory peptides

Role of adhesion receptors in chronic inflammation reviewed

Immunostimulants claimed by Italfarmaco

Pfizer's CJ-12798 claimed as immunosuppressant, antifungal and antitumor agent

MedImmune Lyme disease vaccine shows superior activity in animals

Dacliximab receives patent protection in U.S.

Pharmacia & Upjohn reports taxane derivatives

Antitumor vaccines described by University of Pennsylvania

Human Genome Sciences reports discovery of TNF-gamma

Glaxo Wellcome describes antitumor antibody conjugates

Halistatin 3: Antineoplastic agent of marine origin

Cytotoxic compound eleutherobin reported by University of California

Zeneca reveals antiproliferative aniline derivatives

Kyowa Hakko isolates antitumor/antibacterial compound from Streptomyces

Johns Hopkins researches HIC-1-associated tumor

Somatix gene therapy receives patent coverage

Vertex begins phase II study of VX-710

FDA will review BioLon PMA

HHS scientist discovers cartilage formation stimulant

Fortical phase I dosing data revised

Ono terminates CholestaGel agreement with GelTex

Low-dose lovastatin + niacin shows good efficacy and safety in patient study

Lilly discloses antiobesity proteins

NPY1 ligands claimed by Pfizer

Cathepsin B inhibitor shows potential in gingivitis

New Iomeron formulation introduced in Japan

Anxiolytic/antidepressant 5-HT1A receptor ligands from AHP

5-HT2 ligands claimed by Janssen

Sumitomo claims psychotropic lactam derivatives

RiboGene licenses anti-HIV compounds from Warner-Lambert

Telomere length may reflect disease progression in AIDS patients

Mitotix in-licenses p27 technology

ArQule obtains rights to Yale's alpha-ketoamide chemistry technology

Anergen, Organon to collaborate on RA treatment

Eotaxin receptor cloned: Possible implications for asthma research

Enzo Biochem, St. Luke's collaborate on gene therapy for AIDS

Gilead reports important discovery related to genetic code blocker research

ArQule, ICAgen collaborate on ion channel modulators

Arris, SKB to research protease inhibitors

Cell Genesys forms new subsidiary to develop MAbs

Roche takes over Procter & Gamble share of JV

Alza/HMR and Ciba-Geigy resolve nicotine patch patent disputes

Horiba to acquire ABX from Roche

Bracco Diagnostics takes over marketing from Squibb Diagnostics

Elan-Athena merger approved by stockholders

Glaxo Wellcome divests interest in Warner Wellcome JV

Medeva shareholders OK Rochester take-over

Regeneron, Medtronic to collaborate on Axokine delivery system

Dolasetron equiefficent to granisetron in chemotherapy-induced emesis

Toyama discloses NGF-promoting agents

Anseculin HCl enters phase II clinical trials

Servier's prolyl endopeptidase inhibitor effective in amnesia model

Novo Nordisk claims mGluR antagonists for CNS disorders

NMDA antagonists reported by Zeneca

Cephalon reveals multicatalytic protease inhibitors

New beclomethasone formulation cleared for marketing

Uriach research into PAF antagonists continues

Naphthoquinone derivative selected as potential antiallergic/antiinflammatory

Warner-Lambert reports nonpeptide ET antagonists

First launch for Ciba-Geigy angiotensin II antagonist

TMR with PLC Systems' Heart Laser continues to display efficacy

Alexion begins phase I testing of 5G1.1-SC

AHP describes tricyclic benzazepine vasopressin antagonists

NEP inhibitors claimed by Santen

Kyowa Hakko's OXT displays cardiotonic and insulin release-promoting effects

M2 antagonists reported by Yamanouchi

Excellent antiplatelet activity seen with (R)-(-)-NSP-307

Role of adhesion molecules in hemostasis

Xenova reports on PAI inhibitor R&D

Abbott reports alpha1-antagonists for BPH

Flutamide BPH trial results reported

Ketotifen shown effective in NSAID-induced ulcer model

Good phase I results reported for Campylobacter vaccine

Sankyo discloses sulfonamide derivatives for diabetes

Nippon Chemiphar reports oral hypoglycemic agents for diabetes

Alteon describes new glucose-lowering agent

U.S. clinical trials begin for Ethical Holdings' estradiol patch

Ethical files PLA for estrogen/levonorgestrel patch in U.K.

Memory impairment common side effect of GnRH agonist therapy

Ciba-Geigy introduces Noven's Vivelle in Canada

Oral contraceptive displays cardioprotective effects

Low-estrogen oral contraceptives have low stroke risk

Sandoz reports new NMDA antagonist

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